Current approaches to metastatic colorectal cancer Conference Paper
| Author: | Kemeny, N. |
| Title: | Current approaches to metastatic colorectal cancer |
| Conference Title: | The Community Approach to Salvage Therapy in the Treatment of Advanced Cancer |
| Abstract: | Despite the general perception that chemotherapy for metastatic colorectal cancer is ineffective, over the past decade improvements have been reported. More than 30 years after its introduction into clinical trials, 5- fluorouracil (5-FU) remains the most active single agent in the treatment of metastatic colorectal carcinoma, even though response rates are usually less than 20%. In an effort to improve outcome, investigators have been attempting to exploit the efficacy of 5-FU in various ways. Recent innovations include attempts to biochemically modulate the activity of 5-FU with other drugs, delivering 5-FU by hepatic arterial infusion, and using administration schedules that consider the biology of this tumor and the pharmacokinetics of the drug. Small but clinically significant improvements in efficacy have resulted from these attempts. The results of clinical trials using these approaches and their current and potential future clinical significance are discussed. |
| Keywords: | cancer chemotherapy; cancer survival; controlled study; treatment outcome; hydroxyurea; clinical trial; review; fluorouracil; interferon; cancer combination chemotherapy; drug efficacy; treatment planning; cancer adjuvant therapy; methotrexate; colorectal cancer; metastasis; controlled clinical trial; randomized controlled trial; drug administration schedule; carcinoembryonic antigen; colorectal neoplasms; survival time; drug mechanism; folinic acid; drug response; neoplasm metastasis; intraarterial drug administration; infusions, intra-arterial; drug blood level; clinical trials; hepatic artery; allopurinol; dipyridamole; thymidine derivative; adjuvants, pharmaceutic; sparfosic acid; humans; human; priority journal |
| Journal Title | Seminars in Oncology |
| Volume: | 21 |
| Issue: | 4 Suppl. 7 |
| Conference Dates: | 1993 Jun 18-19 |
| ISBN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1994-08-01 |
| Start Page: | 67 |
| End Page: | 75 |
| Language: | English |
| PUBMED: | 8091243 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 February 2019 -- Source: Scopus |
