Paraneoplastic syndromes Journal Article
| Authors: | Posner, J. B.; Dalmau, J. |
| Article Title: | Paraneoplastic syndromes |
| Abstract: | Paraneoplastic syndromes (i.e. organ/tissue disorders associated with cancer) affecting the nervous system are thought to be the result of an autoimmune response triggered by specific cancer antigens. Several of these antigens have recently been identified and include the Hu, Yo and Ri proteins, with the Hu antigens being the best studied. Immunization of animals with HuD has been shown to retard the growth of HuD-positive neuroblastomas. In addition, the presence of anti-HuD antibody in humans with small-cell lung cancer predicts the slow growth of the tumor. The associated neurological disorders, however, limit the use of these and other antigens with similar characteristics in cancer vaccines. |
| Keywords: | review; nonhuman; tumor antigen; cancer inhibition; lung small cell cancer; cancer vaccine; neuroblastoma; autoimmunity; vaccine production; paraneoplastic syndrome; neurologic disease; antibody production; immunization; cancer antibody; paraneoplastic syndromes; humans; human |
| Journal Title: | Current Opinion in Immunology |
| Volume: | 9 |
| Issue: | 5 |
| ISSN: | 0952-7915 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-10-01 |
| Start Page: | 723 |
| End Page: | 729 |
| Language: | English |
| DOI: | 10.1016/s0952-7915(97)80055-6 |
| PUBMED: | 9368783 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
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