Sonophore labeled RGD: A targeted contrast agent for optoacoustic imaging Journal Article
| Authors: | Haedicke, K.; Brand, C.; Omar, M.; Ntziachristos, V.; Reiner, T.; Grimm, J. |
| Article Title: | Sonophore labeled RGD: A targeted contrast agent for optoacoustic imaging |
| Abstract: | Optoacoustic imaging is a rapidly expanding field for the diagnosis, characterization, and treatment evaluation of cancer. However, the availability of tumor specific exogenous contrast agents is still limited. Here, we report on a small targeted contrast agent for optoacoustic imaging using a black hole quencher® (BHQ) dye. The sonophore BHQ-1 exhibited strong, concentration-dependent, optoacoustic signals in phantoms, demonstrating its ideal suitability for optoacoustic imaging. After labeling BHQ-1 with cyclic RGD-peptide, BHQ-1-cRGD specifically bound to αvβ3-integrin expressing glioblastoma cell spheroids in vitro. The excellent optoacoustic properties of BHQ-1-cRGD could furthermore be proven in vivo. Together with this emerging imaging modality, our sonophore labeled small peptide probe offers new possibilities for non-invasive detection of molecular structures with high resolution in vivo and furthers the specificity of optoacoustic imaging. Ultimately, the discovery of tailor-made sonophores might offer new avenues for various molecular optoacoustic imaging applications, similar to what we see with fluorescence imaging. © 2017 The Authors |
| Keywords: | molecular imaging; diagnosis; peptides; contrast agent; photo-acoustic imaging; rgd peptide; photoacoustic imaging; photoacoustic effect; optoacoustic imaging; gravitation; black hole quencher; sonophore; stars; black holes |
| Journal Title: | Photoacoustics |
| Volume: | 6 |
| ISSN: | 2213-5979 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-06-01 |
| Start Page: | 1 |
| End Page: | 8 |
| Language: | English |
| DOI: | 10.1016/j.pacs.2017.03.001 |
| PROVIDER: | scopus |
| PMCID: | PMC5376267 |
| PUBMED: | 28393018 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2017 -- Source: Scopus |
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