TWH regulates the development of subsets of spinal cord neurons Journal Article

  

Authors:	Dou, C.; Ye, X.; Stewart, C.; Lai, E.; Li, S. C.
Article Title:	TWH regulates the development of subsets of spinal cord neurons
Abstract:	Thymocyte winged helix (TWH) is a putative transcription factor expressed in the developing neural tube. At midgestation, TWH expression identities subsets of spinal cord motor neurons and interneurons. TWH- expressing motor neurons were restricted to specific spinal cord levels, distinguishing motor neurons at lumbar from those at cervical levels. To understand the developmental role of TWH, we replaced the TWH gene with the lacZ reporter gene and generated mice with a homozygous disruption of the TWH gene. TWH((-/-)) mutant mice had increased perinatal mortality, retarded postnatal growth, and motor weakness. The TWH((-/-)) mutation resulted in alterations in the sizes and position of different neuronal populations. Our results demonstrate that TWH plays a critical role in neuronal development and suggest that TWH regulates the early differentiation of neural progenitors.
Keywords:	controlled study; nonhuman; animal cell; mouse; animals; mice; animal tissue; gene targeting; gene expression; embryo; animal experiment; mice, mutant strains; nerve tissue proteins; transcription factor; neurons; central nervous system; transcription factors; molecular sequence data; gene disruption; spinal cord; interneurons; motor neurons; reporter gene; cell count; motor dysfunction; nerve cell differentiation; cell aging; growth retardation; lac operon; spinal cord nerve cell; promoter regions (genetics); perinatal mortality; priority journal; article; embryonic and fetal development
Journal Title:	Neuron
Volume:	18
Issue:	4
ISSN:	0896-6273
Publisher:	Cell Press
Date Published:	1997-04-01
Start Page:	539
End Page:	551
Language:	English
PUBMED:	9136764
PROVIDER:	scopus
DOI:	10.1016/S0896-6273(00)80296-2
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030935696&partnerID=40&md5=841e3c6d4f82c147ff86e4e145464910
Notes:	Article -- Export Date: 17 March 2017 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/108113