Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord Journal Article

   

Authors:	Ashrafi, S.; Betley, J.; Comer, J.; Brenner-Morton, S.; Bar, V.; Shimoda, Y.; Watanabe, K.; Peles, E.; Jessell, T.; Kaltschmidt, J.
Article Title:	Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord
Abstract:	Inhibitory microcircuits are wired with a precision that underlies their complex regulatory roles in neural information processing. In the spinal cord, one specialized class of GABAergic interneurons (GABApre) mediates presynaptic inhibitory control of sensory-motor synapses. The synaptic targeting of these GABAergic neurons exhibits an absolute dependence on proprioceptive sensory terminals, yet the molecular underpinnings of this specialized axoaxonic organization remain unclear. Here, we show that sensory expression of an NB2 (Contactin5)/Caspr4 coreceptor complex, together with spinal interneuron expression of NrCAM/CHL1, directs the high-density accumulation of GABAergic boutons on sensory terminals. Moreover, genetic elimination of NB2 results in a disproportionate stripping of inhibitory boutons from high-density GABApre-sensory synapses, suggesting that the preterminal axons of GABApre neurons compete for access to individual sensory terminals. Our findings define a recognition complex that contributes to the assembly and organization of a specialized GABAergic microcircuit. © 2014 The Authors.
Journal Title:	Neuron
Volume:	81
Issue:	1
ISSN:	0896-6273
Publisher:	Cell Press
Date Published:	2014-01-08
Start Page:	120
End Page:	129
Language:	English
DOI:	10.1016/j.neuron.2013.10.060
PROVIDER:	scopus
PMCID:	PMC3898991
PUBMED:	24411736
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84891809781&partnerID=40&md5=3622af014397b4ae006b71a78dae748d
Notes:	Export Date: 3 February 2014 -- CODEN: NERNE -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/49166