Chromosome 16 in primary prostate cancer: A microsatellite analysis Journal Article

  


Authors: Osman, I.; Scher, H.; Dalbagni, G.; Reuter, V.; Zhang, Z. F.; Cordon-Cardo, C.
Article Title: Chromosome 16 in primary prostate cancer: A microsatellite analysis
Abstract: Cytogenetic and molecular genetic analyses of prostate cancer specimens have revealed nonrandom chromosomal deletions, affecting chromosomes 7q, 8p, 10q and 16q. Based on these data, we designed this study to further characterize the altered region(s) on chromosome 16 by evaluating 16 microsatellite markers on a population composed of 32 paired normal and primary prostatic tumor samples. The 16 microsatellites selected mapped to 11 distinct loci on 16q and 5 loci on 16p. No alterations were identified affecting 16p. However, 16 of 31 (51%) informative cases showed molecular alterations in at least one of the loci analyzed on 16q, consisting of is deletions and 11 bandshifts. Moreover, most of the deletions clustered at 6 microsatellite loci, mapping to the 16q22.1-23.1 region. Our results suggest that microsatellite alterations on the long arm of chromosome 16 are frequent events in prostate cancer, and that the 16q22.1-23.1 region might harbor a tumor suppressor gene involved in prostate cancer.
Keywords: clinical article; controlled study; human tissue; sequence deletion; adenocarcinoma; microsatellite dna; prostate cancer; prostatic neoplasms; chromosome aberration; tumor suppressor gene; dna, neoplasm; chromosome aberrations; genes, tumor suppressor; microsatellite repeats; chromosome 16; chromosomes, human, pair 16; humans; human; male; priority journal; article
Journal Title: International Journal of Cancer
Volume: 71
Issue: 4
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 1997-05-16
Start Page: 580
End Page: 584
Language: English
DOI: 10.1002/(sici)1097-0215(19970516)71:4<580::aid-ijc12>3.0.co;2-g
PUBMED: 9178811
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030990042&doi=10.1002%2f%28SICI%291097-0215%2819970516%2971%3a4%3c580%3a%3aAID-IJC12%3e3.0.CO%3b2-G&partnerID=40&md5=120ee0c2af146ca25dc93ab674690030
Notes: Source: Scopus
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MSK Authors
  1. Guido Dalbagni
    325 Dalbagni
  2. Iman Osman
    36 Osman
  3. Carlos Cordon-Cardo
    612 Cordon-Cardo
  4. Victor Reuter
    1228 Reuter
  5. Howard Scher
    1130 Scher
  6. Zuo-Feng Zhang
    102 Zhang
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