Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors Journal Article
| Authors: | Orlow, I.; Lianes, P.; Lacombe, L.; Dalbagni, G.; Reuter, V. E.; Cordon-Cardo, C. |
| Article Title: | Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors |
| Abstract: | Chromosome 9 allelic losses have been reported as a frequent and early event occurring in bladder cancer. It has been postulated that a candidate tumor suppressor gene may reside on this chromosome, alterations of which may lead to the development of a subset of superficial bladder tumors. More recently, the involvement of two different regions harboring suppressor loci, one on each of both chromosome 9 arms, has been proposed. We undertook the present study with the objectives of better defining the deleted regions of chromosome 9 in bladder tumors, as well as evaluating the frequency of microsatellite alterations affecting certain loci on this chromosome in urothelial neoplasia. Seventy-three primary bladder tumors were analyzed using a set of highly polymorphic markers, and results were correlated with pathological parameters associated with poor clinical outcome. We observed that, overall, 77% of the tumors studied showed either loss of heterozygosity for one or more chromosome 9 markers and/or microstellite abnormalities at chromosome 9 loci. Detailed analyses showed that two regions, one on 9p at the interferon cluster, and the other on 9q associated with the q34.1-2 bands, had the highest frequencies of allelic losses. Furthermore, T, lesions appeared to present mainly with 9q abnormalities, while Tt tumors displayed a mixture of aberrant 9p and 9q genotypes. These observations indicate that loss of heterozygosity of 9p may be associated with the development of superficial tumors with a more aggressive biological behavior or, alternatively, they may be related to early disease progression. In addition, microsatellite alterations were documented in over 40% of amplified cases. Taken together, these data suggest that two different tumor suppressor gene loci on chromosome 9 are involved as tumorigenic events in bladder cancer and that chromosome 9 microsatellite alterations are frequent events occurring in urothelial neoplasia. © 1994, American Association for Cancer Research. All rights reserved. |
| Keywords: | human tissue; gene mutation; human cell; major clinical study; alleles; chromosomes, human, pair 9; bladder tumor; urinary bladder neoplasms; tumor suppressor gene; urothelium; molecular sequence data; base sequence; chromosome deletion; chromosome analysis; chromosome loss; chromosome mapping; chromosome 9; allelism; dna probes; humans; human; priority journal; article; dna, satellite |
| Journal Title: | Cancer Research |
| Volume: | 54 |
| Issue: | 11 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1994-06-01 |
| Start Page: | 2848 |
| End Page: | 2851 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 8187066 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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