Carcinogenesis: A balance between β-catenin and APC Journal Article
| Author: | Gumbiner, B. M. |
| Article Title: | Carcinogenesis: A balance between β-catenin and APC |
| Abstract: | A protein first identified by its association with cadherin cell adhesion molecules, β-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through β-catenin is upregulated either by direct mutation of β-catenin or loss of negative regulation by the APC tumor suppressor protein. |
| Keywords: | dna binding protein; genetics; dna-binding proteins; animal; animals; transcription factor; animalia; transcription factors; gene expression regulation; tumor suppressor gene; gene expression regulation, neoplastic; transactivator protein; trans-activators; beta catenin; drosophila proteins; ctnnb1 protein, human; adenomatous polyposis coli protein; apc protein; genes, tumor suppressor; armadillo domain protein; armadillo domain proteins; armadillo; cytoskeleton protein; drosophila protein; lymphoid enhancer factor 1; lymphoid enhancer-binding factor 1; cytoskeletal proteins; adenomatous polyposis coli; colon polyposis; insect protein; insecta; humans; human; article; insect proteins |
| Journal Title: | Current Biology |
| Volume: | 7 |
| Issue: | 7 |
| ISSN: | 0960-9822 |
| Publisher: | Cell Press |
| Date Published: | 1997-07-01 |
| Start Page: | R443 |
| End Page: | R446 |
| Language: | English |
| PUBMED: | 9210368 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0960-9822(06)00214-4 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
