7-silylcamptothecins (silatecans): A new family of camptothecin antitumor agents Journal Article
| Authors: | Josien, H.; David, B.; Curran, D. P.; Zheng, Y. H.; Chou, T. C. |
| Article Title: | 7-silylcamptothecins (silatecans): A new family of camptothecin antitumor agents |
| Abstract: | The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays. |
| Keywords: | controlled study; unclassified drug; human cell; antineoplastic agent; camptothecin; antineoplastic activity; cytotoxicity; in vitro study; drug synthesis; structure activity relation; tumor cell line; camptothecin derivative; reaction analysis; dna cleavage; human; article; 10 amino 11 fluoro 7 trimethylsilylcamptothecin |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 7 |
| Issue: | 24 |
| ISSN: | 0960-894X |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1997-12-16 |
| Start Page: | 3189 |
| End Page: | 3194 |
| Language: | English |
| DOI: | 10.1016/s0960-894x(97)10181-0 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
