Synthesis of 18-noranhydrocamptothecin analogs which retain topoisomerase I inhibitory function Journal Article

  


Authors: Snyder, L.; Shen, W.; Bornmann, W. G.; Danishefsky, S. J.
Article Title: Synthesis of 18-noranhydrocamptothecin analogs which retain topoisomerase I inhibitory function
Abstract: The total syntheses of compounds 2 and 3 are described. Key departures from previous routes to camptothecin from these laboratories involved (i) early incorporation of C2 oxygen (see compound 9) and (ii) recourse to a Heck vinylation for installation of a hydroxymethyl equivalent on the pyridone (see transformation 15 → 16). The final compounds are of considerable interest in that they are the most drastically modified E ring systems which retain topoisomerase I inhibitory function. © 1994, American Chemical Society. All rights reserved.
Keywords: unclassified drug; enzyme inhibition; drug synthesis; structure activity relation; camptothecin derivative; reaction analysis; dna topoisomerase; article; 18 noranhydrocamptothecin
Journal Title: Journal of Organic Chemistry
Volume: 59
Issue: 23
ISSN: 0022-3263
Publisher: American Chemical Society  
Date Published: 1994-11-01
Start Page: 7033
End Page: 7037
Language: English
DOI: 10.1021/jo00102a030
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028113185&doi=10.1021%2fjo00102a030&partnerID=40&md5=8702fc2e762402fea05d48c22b9e11f3
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
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MSK Authors
  1. William Bornmann
    112 Bornmann
  2. Samuel J Danishefsky
    539 Danishefsky
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