Pediatric rhabdomyosarcoma of the head and neck Journal Article
| Authors: | Kraus, D. H.; Saenz, N. C.; Gollamudi, S.; Heller, G.; Moustakis, M.; Gardiner, S.; Gerald, W. L.; Ghavimi, F.; LaQuaglia, M. P. |
| Article Title: | Pediatric rhabdomyosarcoma of the head and neck |
| Abstract: | PURPOSE: Survival for pediatric rhabdomyosarcoma has improved with the use of multidrug chemotherapy and external beam radiotherapy. This study was performed to determine survival in a cohort of patients treated on one of three multidrug treatment protocols for head and neck rhabdomyosarcoma and to identify factors that place patients at risk for treatment failure. METHODS: Pertinent prognostic variables including age, sex, subsite of origin, resectability, and TNM stage were analyzed by the Kaplan-Meier methods with comparisons between variables performed using the Prentice-Wilcoxon test statistic. RESULTS: Overall 5-year survival was 74% (95% confidence interval 64% to 84%). Local failure accounted for the cause of death in 10 patients, and 8 died of disseminated disease. On univariate analysis, each variable contributing to the TNM staging system was significant in determining survival; invasiveness (P = 0.01), size (P = 0.02), nodal metastases (P <0.01), and distant disease (P <0.01). CONCLUSION: Survival has improved for head and neck rhabdomyosarcoma treated with multimodality therapy. Patients with advanced-stage disease are at greatest risk for treatment failure and require the most aggressive therapy. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; child; survival analysis; survival rate; treatment failure; retrospective studies; major clinical study; doxorubicin; cancer radiotherapy; combined modality therapy; methotrexate; cancer staging; follow-up studies; neoplasm staging; etoposide; risk factors; cyclophosphamide; vincristine; risk factor; carmustine; ifosfamide; childhood cancer; time factors; infant; head and neck cancer; head and neck neoplasms; dactinomycin; bleomycin; rhabdomyosarcoma; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | American Journal of Surgery |
| Volume: | 174 |
| Issue: | 5 |
| ISSN: | 0002-9610 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-11-01 |
| Start Page: | 556 |
| End Page: | 560 |
| Language: | English |
| DOI: | 10.1016/s0002-9610(97)00171-2 |
| PUBMED: | 9374237 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Presented at the 43rd Annual Meeting of the Society of Head and Neck Surgeons that took place 1997 Apr 10-12 in Cancun, Mexico -- Export Date: 17 March 2017 -- Source: Scopus |
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