Soft tissue sarcoma of the head & neck: Nomogram validation and analysis of staging systems Journal Article
| Authors: | Shuman, A. G.; Brennan, M. F.; Palmer, F. L.; Kuk, D.; Moraco, N.; Singer, S.; Shah, J. P.; Patel, S. G. |
| Article Title: | Soft tissue sarcoma of the head & neck: Nomogram validation and analysis of staging systems |
| Abstract: | Background and Objectives Soft tissue sarcomas of the head and neck (STSHN) comprise a rare group of malignancies. Our objective is to determine the utility of soft tissue sarcoma staging systems within the head and neck, and to validate an individualized soft tissue sarcoma nomogram within head and neck primary sites. Methods Previously-untreated patients with STSHN diagnosed and treated between 1982 and 2012 were eligible (n = 319, median follow-up 46 months). Clinical variables were extracted from a prospectively-maintained database. The performance of AJCC/UICC and MSK staging systems and a soft tissue sarcoma-specific nomogram were assessed. Results Four-year overall survival (OS), disease specific survival (DSS), and recurrence-free survival (RFS) were 72%, 76%, and 71%, respectively. AJCC/UICC and MSK staging systems accurately stratified outcomes (OS, DSS, and RFS; P < 0.001 for all comparisons). The nomogram stratified outcomes by quartile (P < 0.001), and predicted risk of death at 4, 8 and 12 years (P < 0.001). Concordance indices for overall survival for the AJCC/UICC system, MSK system, and the nomogram were 0.71, 0.70, and 0.78, respectively. Conclusions Oncologic outcomes among groups of patients with STSHN can be accurately predicted using both the AJCC/UICC and MSK staging systems. A soft tissue sarcoma-specific nomogram provides reliable, individualized prognostic information for patients with STSHN. © 2015 Wiley Periodicals, Inc. |
| Keywords: | staging; head and neck cancer; nomograms; soft tissue sarcoma |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 111 |
| Issue: | 6 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2015-05-01 |
| Start Page: | 690 |
| End Page: | 695 |
| Language: | English |
| DOI: | 10.1002/jso.23868 |
| PROVIDER: | scopus |
| PUBMED: | 25711850 |
| PMCID: | PMC5827948 |
| DOI/URL: | |
| Notes: | Export Date: 4 May 2015 -- Source: Scopus |
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