Intensity-modulated radiotherapy for head-and-neck rhabdomyosarcoma Journal Article
| Authors: | Wolden, S. L.; Wexler, L. H.; Kraus, D. H.; LaQuaglia, M. P.; Lis, E.; Meyers, P. A. |
| Article Title: | Intensity-modulated radiotherapy for head-and-neck rhabdomyosarcoma |
| Abstract: | Purpose: To determine the preliminary results of intensity-modulated radiotherapy (IMRT) for head-and-neck rhabdomyosarcoma. Methods and Materials: Twenty-eight patients underwent IMRT as a part of multimodality therapy. Twenty-one tumors were parameningeal, three were orbital, and four were in other sites. The median age was 8 years (range, 1-29 years). Most (89%) had Group III disease. Intracranial extension was present in 71% of parameningeal tumors. A 1.5-cm margin was used, and the median dose was 50.4 Gy (range, 30-55.8 Gy). Results: The actuarial 3-year survival rate for patients with parameningeal tumors was 65%. The 3-year actuarial freedom from failure rate was 95% locally, 90% in regional nodes, 88% in the central nervous system, and 80% at distant sites. No failures occurred among patients with orbit tumors; a single central nervous system failure occurred in 1 patient with a lip/cheek tumor. Disease-free survival was significantly worse for patients with alveolar histologic features (p = 0.01). Acute radiation toxicity was similar to that reported by the Intergroup Rhabdomyosarcoma Study Group. Late radiation toxicity was recorded and was mild. Conclusion: IMRT with image fusion results in outstanding local control despite the use of a reduced margin. However, survival among patients with alveolar histologic findings or intracranial extension remains unacceptably low. © 2005 Elsevier Inc. |
| Keywords: | adolescent; adult; cancer survival; child; clinical article; child, preschool; disease-free survival; cancer patient; cancer radiotherapy; tumor localization; metastasis; radiotherapy dosage; radiotherapy; patient monitoring; histology; groups by age; central nervous system; statistical significance; infant; head and neck cancer; intensity-modulated radiotherapy; tumors; head and neck neoplasms; dosimetry; imaging; radiotherapy, conformal; cancer control; rhabdomyosarcoma; toxicity; head and neck; diseases; orbit tumor; neurology; dosimeters; multimodality therapy; intensity-modulated radiotherapy (imrt); lip tumor; intracranial extension; recording |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 61 |
| Issue: | 5 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-04-01 |
| Start Page: | 1432 |
| End Page: | 1438 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2004.08.005 |
| PUBMED: | 15817347 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 33" - "Export Date: 24 October 2012" - "CODEN: IOBPD" - "Source: Scopus" |
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