The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis Journal Article
| Authors: | Verheij, M.; Ruiter, G. A.; Zerp, S. F.; Van Blitterswijk, W. J.; Fuks, Z.; Haimovitz-Friedman, A.; Bartelink, H. |
| Article Title: | The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis |
| Abstract: | Ionizing radiation, like a variety of other cellular stress factors, initiates apoptosis, or programmed cell death, in many cell systems. This mode of radiation-induced cell kill should be distinguished from clonogenic cell death due to unrepaired DNA damage. Ionizing radiation not only exerts its effect on the nuclear DNA, but also at the plasma membrane level where it may activate multiple signal transduction pathways. One of these pathways is the stress-activated protein kinase (SAPK) cascade which transduces death signals from the cell membrane to the nucleus. This review discusses recent evidence on the critical role of this signaling system in radiation- and stress-induced apoptosis. An improved understanding of the mechanisms involved in radiation-induced apoptosis may ultimately provide novel strategies of intervention in specific signal transduction pathways to favorably alter the therapeutic ratio in the treatment of human malignancies. |
| Keywords: | signal transduction; unclassified drug; human cell; review; nonhuman; animal cell; apoptosis; radiation; stress activated protein kinase; enzyme activation; tumor cells, cultured; endothelium, vascular; ionizing radiation; stress; mitogen-activated protein kinases; protein kinase; jnk mitogen-activated protein kinases; ca(2+)-calmodulin dependent protein kinase; humans; human; priority journal; sapk/jnk |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 47 |
| Issue: | 3 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1998-06-01 |
| Start Page: | 225 |
| End Page: | 232 |
| Language: | English |
| DOI: | 10.1016/s0167-8140(98)00007-3 |
| PUBMED: | 9681884 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
