Radiation induction of immediate early genes: Effectors of the radiation-stress response Journal Article
| Authors: | Weichselbaum, R. R.; Hallahan, D.; Fuks, Z.; Kufe, D. |
| Article Title: | Radiation induction of immediate early genes: Effectors of the radiation-stress response |
| Abstract: | Recent studies have demonstrated that the early response genes c-jun, Egr-1, c-fos, and NFKB are induced following exposure of mammalian cells to ionizing radiation. We propose that the products of these early response genes regulate downstream genes that are important in the adaptation of cells and tissues to radiation-induced stress. Potential downstream targets include cytokine and growth factor genes as well as deoxyribonucleic acid (DNA) repair genes. Early response gene products may also regulate cell cycle progression following cellular x-irradiation. Signal transduction pathways that allow cells to adapt to radiation may provide molecular targets to modify tumor and normal responses to radiotherapy. © 1994. |
| Keywords: | signal transduction; platelet derived growth factor; human cell; nonhuman; animal cell; animal; cell cycle; dna repair; transforming growth factor beta; immunoglobulin enhancer binding protein; transcription, genetic; radiation response; gene expression regulation; cytokine; molecular sequence data; tumor necrosis factor alpha; reactive oxygen species; ionizing radiation; base sequence; stress; protein kinase c; oxidative stress; gene induction; superoxide dismutase; growth factor; x irradiation; mammal cell; interleukin 1; radiation injuries, experimental; manganese; basic fibroblast growth factor; genes, regulator; stress response; growth factors; human; priority journal; article; immediate early gene; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; oncogene c fos; oncogene c jun; early response genes; radiation mediated transcription |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 30 |
| Issue: | 1 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1994-08-30 |
| Start Page: | 229 |
| End Page: | 234 |
| Language: | English |
| DOI: | 10.1016/0360-3016(94)90539-8 |
| PROVIDER: | scopus |
| PUBMED: | 8083118 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
