Quantitative assessment of bone marrow hematopoiesis using parametric magnetic resonance imaging Journal Article


Authors: Ballon, D.; Jakubowski, A. A.; Tulipano, P. K.; Graham, M. C.; Schneider, E.; Aghazadeh, B.; Chen, Q. S.; Koutcher, J. A.
Article Title: Quantitative assessment of bone marrow hematopoiesis using parametric magnetic resonance imaging
Abstract: Spatial maps of the percentage cellularity in pelvic bone marrow were calculated at a resolution of 15.6 mm3 from six volunteers and 10 patients treated for documented hematologic disease using a three-point Dixon MRI pulse sequence. The percentage cellularity calculation was aided by analyzing a two-dimensional feature space consisting of the apparent water fraction (Wα), and the T(a) relaxation time of water (T(2w)). An extracellular water fraction was assigned to each voxel on the basis of s two-component T(2w) algorithm. In six cases, the method was compared to results obtained from core biopsies or aspirates of the posterior iliac crest. The results indicate that segmentation schemes that combine high-quality phase-contrast imaging with nuclear relaxation time measurements can potentially identify the true fractional marrow volume occupied by hematopoietic elements in a variety of clinical situations.
Keywords: adult; clinical article; controlled study; middle aged; case-control studies; nuclear magnetic resonance imaging; magnetic resonance imaging; bone marrow; diagnostic imaging; algorithms; biopsy; diagnostic value; hematopoiesis; image processing, computer-assisted; hematologic disease; hematologic diseases; myeloid leukemia; ilium; quantitative diagnosis; humans; human; male; female; article; parametric imaging; bone marrow imaging; dixon method
Journal Title: Magnetic Resonance in Medicine
Volume: 39
Issue: 5
ISSN: 0740-3194
Publisher: John Wiley & Sons  
Date Published: 1998-05-01
Start Page: 789
End Page: 800
Language: English
DOI: 10.1002/mrm.1910390517
PUBMED: 9581611
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Douglas J Ballon
    33 Ballon
  2. Jason A Koutcher
    236 Koutcher
  3. Martin C Graham
    29 Graham