Strategy in oligosaccharide synthesis: An application to a concise total synthesis of the KH-1(adenocarcinoma) antigen Journal Article
| Authors: | Deshpande, P. P.; Kim, H. M.; Zatorski, A.; Park, T. K.; Ragupathi, G.; Livingston, P. O.; Live, D.; Danishefsky, S. J. |
| Article Title: | Strategy in oligosaccharide synthesis: An application to a concise total synthesis of the KH-1(adenocarcinoma) antigen |
| Abstract: | A concise and potentially practical synthesis of the title compound has been achieved. The route features a high degree of convergence and economy of synthetic operations. A key step is the concurrent introductory addition of three α-1-fucosyl residues at required hydroxyl acceptor sites (see 37 → 39). Conjugation to carrier protein was achieved, and a route to include truncated structures for investigations for antibody specificity was accomplished. |
| Keywords: | cancer diagnosis; adenocarcinoma; tumor antigen; antibody specificity; colon carcinoma; covalent bond; carbohydrate synthesis; article |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 120 |
| Issue: | 7 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 1998-02-25 |
| Start Page: | 1600 |
| End Page: | 1614 |
| Language: | English |
| DOI: | 10.1021/ja9725864 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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23Zatorski -
144Ragupathi -
539Danishefsky -
228Livingston -
6
Kim -
12Park
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