Immunoreactivity for A103, an antibody to Melan-A (Mart-1), in adrenocortical and other steroid tumors Journal Article
| Authors: | Busam, K. J.; Iversen, K.; Coplan, K. A.; Old, L. J.; Stockert, E.; Chen, Y. T.; McGregor, D.; Jungbluth, A. |
| Article Title: | Immunoreactivity for A103, an antibody to Melan-A (Mart-1), in adrenocortical and other steroid tumors |
| Abstract: | The Melan-A (MART-I) gene encodes an antigen recognized by cytotoxic T cells. It has been said to be restricted in its expression to melanocytes. However, here we report the presence of immunoreactivity for A 103, an antibody to Melan-A, in five adrenocortical adenomas, 16 primary and 13 metastatic adrenocortical carcinomas, four Leydig cell tumors of the testis, and three Sertoli-Leydig cell tumors of the ovary. To evaluate the potential diagnostic role of this antibody, we studied immunoreactivity for A103 in 111 carcinomas, 40 germ cell tumors, and 33 miscellaneous nonmelanocytic epithelioid tumors. All of them were negative for A103. Our findings suggest that once melanoma is excluded, A103 can aid in the recognition of steroid hormone-producing tumors and may be particularly useful in the diagnosis of adrenocortical carcinoma. The presence of immunoreactivity for A103 practically excludes any other carcinoma that may enter into the differential diagnosis of adrenocortical tumors. |
| Keywords: | clinical article; human tissue; cancer diagnosis; animals; mice; melanoma; ovary cancer; melanocytes; neoplasm proteins; immunoreactivity; monoclonal antibody; adrenal cortex carcinoma; urogenital neoplasms; immunoenzyme techniques; antibodies, monoclonal; antigens, neoplasm; diagnostic value; testis cancer; antibodies, neoplasm; adrenocortical carcinoma; adrenal cortex neoplasms; cross reactions; leydig cell tumor; melan-a; adrenocortical adenoma; adrenocortical tumors; mart-1; humans; human; male; female; article; adrenal cortex adenoma; sertoli cell tumor; sertoli-leydig cell tumor; steroid tumors |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 22 |
| Issue: | 1 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1998-01-01 |
| Start Page: | 57 |
| End Page: | 63 |
| Language: | English |
| DOI: | 10.1097/00000478-199801000-00007 |
| PUBMED: | 9422316 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work