Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation Journal Article

Authors: Basu, U.; Franklin, A.; Schwer, B.; Cheng, H. L.; Chaudhuri, J.; Alt, F. W.
Article Title: Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation
Abstract: Human and mouse Ig genes are diversified in mature B-cells by distinct processes known as Ig heavy-chain CSR (class switch recombination) and Ig variable-region exon SHM (somatic hypermutation). These DNA-modification processes are initiated by AID (activation-induced cytidine deaminase), a DNA cytidine deaminase predominantly expressed in activated B-cells. AID is post-transcriptionally regulated via multiple mechanisms, including microRNA regulation, nucleocytoplasmic shuttling, ubiquitination and phosphorylation. Among these regulatory processes, AID phosphorylation at Ser<sup>38</sup> has been a focus of particularly intense study and debate. In the present paper, we discuss recent biochemical and mouse genetic studies that begin to elucidate the functional significance of AID Ser<sup>38</sup> phosphorylation in the context of the evolution of this mode of AID regulation and the potential roles that it may play in activated B-cells during a normal immune response. © The Authors Journal compilation © 2009 Biochemical Society.
Keywords: protein expression; protein phosphorylation; exon; mutation; nonhuman; conference paper; mouse mutant; animals; mice; microrna; serine; genetic variability; evolution; enzyme activity; phosphorylation; b lymphocyte; b-lymphocytes; evolution, molecular; molecular mechanics; lymphocyte activation; activation-induced cytidine deaminase (aid); class switch recombination; somatic hypermutation; activation induced cytidine deaminase; dna; double stranded dna; immunoglobulin heavy chain; cellular immunity; deamination; dna modification; enzyme phosphorylation; enzyme regulation; gene rearrangement; genetic recombination; immune response; immunoglobulin gene; immunoglobulin variable region; molecular evolution; nucleocytoplasmic transport; protein processing; regulatory mechanism; transcription regulation; ubiquitination; amino acid sequence; conserved sequence; cytidine deaminase; immunoglobulin heavy chains; molecular sequence data; protein processing, post-translational; sequence homology, amino acid; species specificity
Journal Title: Biochemical Society Transactions
Volume: 37
Issue: 3
ISSN: 0300-5127
Publisher: Portland Press Ltd  
Date Published: 2009-06-01
Start Page: 561
End Page: 568
Language: English
DOI: 10.1042/bst0370561
PUBMED: 19442251
PROVIDER: scopus
PMCID: PMC3540414
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: BCSTB" - "Source: Scopus"
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