Regulation of activation induced deaminase via phosphorylation Journal Article

  


Authors: Basu, U.; Chaudhuri, J.; Phan, R. T.; Datta, A.; Alt, F. W.
Article Title: Regulation of activation induced deaminase via phosphorylation
Abstract: Immunoglobulin gene diversification by somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion is dependent upon activation-induced cytidine deaminase (AID). AID is a single-stranded DNA specific cytidine deaminase that is expressed primarily in activated mature B lymphocytes. AID appears to catalyze DNA cytidine deamination of immunoglobulin heavy (IgH) and light chain (IgL) variable region (V) exons and IgH switch (S) region sequences to initiate, respectively, IgH and IgL somatic hypermutation (SHM) and IgH class switch recombination (CSR). Here, we will discuss the implications of recent studies that demonstrate the role of AID phosphorylation in augmenting AID activity with respect to these two processes. © 2007 Springer Science+Business Media, LLC.
Keywords: unclassified drug; review; nonhuman; conference paper; flow cytometry; animal; metabolism; animals; enzyme activation; enzymology; enzyme activity; phosphorylation; b lymphocyte; b-lymphocytes; activation induced cytidine deaminase; dna; deamination; enzyme phosphorylation; enzyme regulation; protein processing; cytidine deaminase; protein processing, post-translational; catalysis; single stranded dna; enzyme modification; cytidine; aicda (activation induced cytidine deaminase); aicda (activation-induced cytidine deaminase)
Journal Title: Advances in Experimental Medicine and Biology
Volume: 596
ISSN: 0065-2598
Publisher: Springer  
Date Published: 2007-01-01
Start Page: 129
End Page: 137
Language: English
DOI: 10.1007/0-387-46530-8-11
PUBMED: 17338181
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-34247617340&partnerID=40&md5=fd6cf3885c43ac7fbfb0983f8867c6e6
Notes: Chapter 11 in "Mechanisms of Lymphocyte Activation and Immune Regulation XI" (ISBN: 978-0-387-46527-2) - "Cited By (since 1996): 13" - "Export Date: 17 November 2011" - "CODEN: AEMBA" - "Source: Scopus"
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MSK Authors
  1. Jayanta Chaudhuri
    71 Chaudhuri
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