Cutting edge: The transcription factor Sox2 regulates AID expression in class-switched B cells Journal Article


Authors: DiMenna, L. J.; Yen, W. F.; Nicolas, L.; Sharma, R.; Saldanha, Z. N.; Chaudhuri, J.
Article Title: Cutting edge: The transcription factor Sox2 regulates AID expression in class-switched B cells
Abstract: IgH class switch recombination (CSR) occurs through the deliberate introduction of activation-induced cytidine deaminase (AID)-instigated DNA double-strand breaks into the IgH loci. Because double-strand breaks are generally highly toxic, mechanisms that regulate AID expression are of much relevance to CSR and genomic integrity; however, effectors of such regulatory processes are still poorly understood. In this article, we show that the transcription factor sex determining region Y-box 2 (Sox2) is expressed in activated B cells, but almost exclusively in those that have undergone CSR. We demonstrate that enforced expression of Sox2 in splenic B cells severely inhibits AID expression and CSR, whereas deletion of Sox2 increases the frequency of IgH:c-Myc translocations. These results suggest that Sox2 may regulate AID expression in class-switched B cells to suppress genomic instability associated with CSR. Copyright © 2017 by The American Association of Immunologists, Inc.
Journal Title: Journal of Immunology
Volume: 198
Issue: 6
ISSN: 0022-1767
Publisher: The American Association of Immunologists, Inc  
Date Published: 2017-03-15
Start Page: 2244
End Page: 2248
Language: English
DOI: 10.4049/jimmunol.1502266
PROVIDER: scopus
PMCID: PMC5373658
PUBMED: 28188246
DOI/URL:
Notes: Article -- Export Date: 3 April 2017 -- Source: Scopus
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MSK Authors
  1. Wei-Feng Yen
    10 Yen
  2. Rahul Sharma
    3 Sharma