The ENETS/WHO grading system for neuroendocrine neoplasms of the gastroenteropancreatic system: A review of the current state, limitations and proposals for modifications Journal Article

   

Authors:	Cavalcanti, M. S.; Gönen, M.; Klimstra, D. S.
Article Title:	The ENETS/WHO grading system for neuroendocrine neoplasms of the gastroenteropancreatic system: A review of the current state, limitations and proposals for modifications
Abstract:	The understanding of neuroendocrine neoplasms has evolved significantly since their initial descriptions in the 1800s to early 1900s. In the gastroenteropancreatic system, this group of malignant tumors is subdivided into well and poorly differentiated neuroendocrine neoplasms based on morphologic, proliferative and biologic differences. However, it has become increasingly apparent that well-differentiated neuroendocrine tumors are not a homogeneous group. Attempting to better predict outcome of these tumors has been the motivation behind numerous proposed classification systems, the evolution of which culminated with the currently used system, the ENETS/WHO classification. Herein, we review the genesis of this classification system and some of its shortcomings. In addition, we discuss some of the most recent proposals that suggest modifications to the current system.
Keywords:	consensus; guidelines; prognostic-factors; liver metastases; proliferative index; ki67; american joint committee; pancreatic endocrine tumors; mitotic count; interobserver reproducibility; ki-67 labeling index; staging-systems
Journal Title:	International Journal of Endocrine Oncology
Volume:	3
Issue:	3
ISSN:	2045-0869
Publisher:	Future Medicine
Date Published:	2016-08-01
Start Page:	203
End Page:	219
Language:	English
ACCESSION:	WOS:000387501100003
DOI:	10.2217/ije-2016-0006
PROVIDER:	wos
PMCID:	PMC6190579
PUBMED:	30338051
Notes:	Review -- Source: Wos

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