Neuroendocrine neoplasms of the lung and gastrointestinal system: convergent biology and a path to better therapies Review
| Authors: | Kawasaki, K.; Rekhtman, N.; Quintanal-Villalonga, Á; Rudin, C. M. |
| Review Title: | Neuroendocrine neoplasms of the lung and gastrointestinal system: convergent biology and a path to better therapies |
| Abstract: | Neuroendocrine neoplasms (NENs) can develop in almost any organ and span a spectrum from well-differentiated and indolent neuroendocrine tumours (NETs) to poorly differentiated and highly aggressive neuroendocrine carcinomas (NECs), including small-cell lung cancer (SCLC). These neoplasms are thought to primarily derive from neuroendocrine precursor cells located throughout the body and can also arise through neuroendocrine transdifferentiation of organ-specific epithelial cell types. Hence, NENs constitute a group of tumour types that share key genomic and phenotypic characteristics irrespective of their site of origin, albeit with some organ-specific differences. The establishment of representative preclinical models for several of these disease entities together with analyses of human tumour specimens has provided important insights into crucial aspects of their biology with therapeutic implications. In this Review, we provide a comprehensive overview of the current understanding of NENs of the gastrointestinal system and lung from clinical and biological perspectives. Research on NENs has typically been siloed by the tumour site of origin, and a cross-cutting view might enable advances in one area to accelerate research in others. Therefore, we aim to emphasize that a better understanding of the commonalities and differences of NENs arising in different organs might more effectively inform clinical research to define therapeutic targets and ultimately optimize patient care. © 2022, Springer Nature Limited. |
| Keywords: | immunohistochemistry; overall survival; somatic mutation; disease course; review; cisplatin; fluorouracil; sunitinib; cancer risk; pancreatic neoplasms; cancer staging; phenotype; metabolism; demography; carboplatin; biology; etoposide; lung neoplasms; gene frequency; pathology; carcinogenesis; irinotecan; neuroendocrine tumor; gastrointestinal neoplasms; lung tumor; patient care; medical research; pancreas tumor; carcinoma; lung; cytoplasm; octreotide; paraneoplastic syndrome; everolimus; inappropriate vasopressin secretion; angiopeptin; neuroendocrine tumors; carcinoma, neuroendocrine; small cell lung cancer; small cell lung carcinoma; streptozocin; insulinoma; large cell neuroendocrine carcinoma; tumor microenvironment; carcinoid syndrome; gastrointestinal tumor; gastrinoma; glucagonoma; somatostatinoma; vipoma; germline mutation; gastroenteropancreatic neuroendocrine tumor; cancer prognosis; humans; human; durvalumab; atezolizumab; single cell rna seq; tobacco consumption; oxodotreotide lutetium lu 177; pulmonary carcinoid |
| Journal Title: | Nature Reviews Clinical Oncology |
| Volume: | 20 |
| Issue: | 1 |
| ISSN: | 1759-4774 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2023-01-01 |
| Start Page: | 16 |
| End Page: | 32 |
| Language: | English |
| DOI: | 10.1038/s41571-022-00696-0 |
| PUBMED: | 36307533 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding author is MSK author Charles M. Rudin -- Export Date: 3 January 2023 -- Source: Scopus |
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