Feasibility of a modified biopsy needle for irreversible electroporation ablation and periprocedural tissue sampling Journal Article
| Authors: | Wimmer, T.; Srimathveeravalli, G.; Silk, M.; Monette, S.; Gutta, N.; Maybody, M.; Erinjeri, J. P.; Coleman, J. A.; Solomon, S. B.; Sofocleous, C. T. |
| Article Title: | Feasibility of a modified biopsy needle for irreversible electroporation ablation and periprocedural tissue sampling |
| Abstract: | Objectives: To test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy. Methods: Core biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was performed in in vivo porcine kidneys with pairs of experimental (n = 10) or standard probes (n = 10) using a single parameter set (1667 V/cm, ninety 100 µs pulses). Two biopsy samples were taken immediately following ablation using the experimental probes (n = 20). Ablation outcomes were compared using computed tomography, simulation, and histology. Biopsy and necropsy histology were compared. Results: Simulation-suggested ablations with experimental probes were smaller than that with standard electrodes (455.23 vs 543.16 mm2), although both exhibited similar shape. Computed tomography (standard: 556 ± 61 mm2, experimental: 515 ± 67 mm2; P =.25) and histology (standard: 313 ± 77 mm2, experimental: 275 ± 75 mm2; P =.29) indicated ablations with experimental probes were not significantly different from the standard. Histopathology indicated similar morphological changes in both groups. Biopsies from the ablation zone yielded at least 1 core with sufficient tissue for analysis (11 of the 20). Conclusions: A combined probe for irreversible electroporation ablation and periprocedural tissue sampling from the ablation zone is feasible. Ablation outcomes are comparable to those of standard electrodes. © 2015, © The Author(s) 2015. |
| Keywords: | kidney; computed tomography; core needle biopsy; irreversible electroporation; ablation technique |
| Journal Title: | Technology in Cancer Research & Treatment |
| Volume: | 15 |
| Issue: | 6 |
| ISSN: | 1533-0346 |
| Publisher: | Sage Publications |
| Date Published: | 2016-12-01 |
| Start Page: | 749 |
| End Page: | 758 |
| Language: | English |
| DOI: | 10.1177/1533034615608739 |
| PROVIDER: | scopus |
| PUBMED: | 26443800 |
| PMCID: | PMC5495023 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 December 2016 -- Source: Scopus |
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