Fatal hepatitis B reactivation in a patient with islet cell tumor on octreotide and sirolimus Journal Article
| Authors: | DeFilippis, E. M.; Ludwig, E. |
| Article Title: | Fatal hepatitis B reactivation in a patient with islet cell tumor on octreotide and sirolimus |
| Abstract: | Reactivation of hepatitis B viral infection (HBVr) is a known risk in cancer patients with a history of chronic hepatitis B infection receiving cytotoxic or immunosuppressive therapies. Patients with hematologic malignancies or those who have received stem cell transplantation seem to be most at risk but reactivation has been reported with various malignancies. Reactivation can present as asymptomatic liver function test abnormalities (LFTs), with symptoms of abdominal pain, encephalopathy, or as fulminant hepatitis and liver failure. Here we report the first case of a patient with islet cell tumor on octreotide and sirolimus who developed hepatitis B reactivation with fulminant liver failure and death. © Journal of Gastrointestinal Oncology. |
| Keywords: | adult; middle aged; disease course; fatigue; case report; artificial embolism; hepatitis b; liver dysfunction; computer assisted tomography; alanine aminotransferase blood level; aspartate aminotransferase blood level; alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; cause of death; confusion; hypotension; liver failure; liver metastasis; brain disease; nausea and vomiting; hospital admission; alkaline phosphatase blood level; octreotide; weakness; liver function test; drug treatment failure; hypoxemia; bilirubin blood level; serology; rapamycin; sirolimus; multiple organ failure; virus reactivation; lamivudine; antiviral agents; pancreas islet cell tumor; lactulose; rifaximin; neomycin; islet cell; oliguria; spleen metastasis; adefovir; human; male; article; hepatitis b surface antigen |
| Journal Title: | Journal of Gastrointestinal Oncology |
| Volume: | 6 |
| Issue: | 5 |
| ISSN: | 2078-6891 |
| Publisher: | Pioneer Bioscience Publishing Company |
| Date Published: | 2015-10-01 |
| Start Page: | E66 |
| End Page: | E69 |
| Language: | English |
| DOI: | 10.3978/j.issn.2078-6891.2015.042 |
| PROVIDER: | scopus |
| PMCID: | PMC4570918 |
| PUBMED: | 26487953 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 December 2016 -- Source: Scopus |
