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Natalya Gestsik

Formats
  1. Journal Article (6)
  2. Book Section (1)
  3. Meeting Abstract (1)
Groups
  1. GSK Faculty (8)
  2. Molecular Pharmacology and Chemistry Program Faculty (8)
  3. Population Sciences Research Program (8)
  4. Sloan Kettering Institute Faculty (8)
  5. Sloan Kettering Institute Postdocs (1)
People
  1. Yueming Li (8)
  2. Christina Crump (2)
  3. Deming Chau (2)
  4. Danica Chiu (1)
  5. Ji Yeun Hur (1)
  6. Kwangwook Ahn (1)

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Years
  1. 2017 (2)
  2. 2016 (2)
  3. 2015 (2)
  4. 2014 (1)
  5. 2011 (1)
Publications
  1. ACS Chemical Neuroscience (2)
  2. ACS Chemical Biology (1)
  3. Abstracts of Papers of the American Chemical Society (1)
  4. Cell Chemical Biology (1)
  5. Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. 1st ed (1)
  6. Frontiers in Aging Neuroscience (1)

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Publishers
  1. American Chemical Society (4)
  2. Cell Press (1)
  3. Elsevier Inc. (1)
  4. Frontiers Research Foundation (1)
  5. Royal Society of Chemistry (1)

Results (8)

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  • Cleavable photoprobes enable binding site identification of a gamma secretase inhibitor
    Meeting Abstract

    Ende, C. A.; Gertsik, N.; Geoghegan, K.; Nguyen, C.; Mukherjee, P.; Mente, S.; Seneviratne, U.; Johnson, D.; Li, Y. M.
    Abstracts of Papers of the American Chemical Society (2017)

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  • Mapping the binding site of BMS-708163 on γ-secretase with cleavable photoprobes
    Journal Article

    Gertsik, N.; am Ende, C. W.; Geoghegan, K. F.; Nguyen, C.; Mukherjee, P.; Mente, S.; Seneviratne, U.; Johnson, D. S.; Li, Y. M.
    Cell Chemical Biology (2017)

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  • γ-secretase inhibitors: From chemical probes to drug development
    Book Section

    Hur, J. Y.; Gertsik, N.; Johnson, D. S.; Li, Y. M.
    In Wolfe, M. S. (Eds.) Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. 1st ed (2016)

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  • Development of sulfonamide photoaffinity inhibitors for probing cellular γ-secretase
    Journal Article

    Crump, C. J.; Murrey, H. E.; Ballard, T. E.; am Ende, C. W.; Wu, X.; Gertsik, N.; Johnson, D. S.; Li, Y. M.
    ACS Chemical Neuroscience (2016)

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  • Gamma-secretase inhibitors and modulators induce distinct conformational changes in the active sites of gamma-secretase and signal peptide peptidase
    Journal Article

    Gertsik, N.; Chau, D. M.; Li, Y. M.
    ACS Chemical Biology (2015)

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  • Complex regulation of γ-secretase: From obligatory to modulatory subunits
    Journal Article

    Gertsik, N.; Chiu, D.; Li, Y. M.
    Frontiers in Aging Neuroscience (2015)

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  • Development of CBAP-BPyne, a probe for γ-secretase and presenilinase
    Journal Article

    Gestsik, N.; Ballard, T. E.; Am Ende, C. W.; Johnson, D. S.; Li, Y. M.
    MedChemComm (2014)

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  • Piperidine acetic acid based γ-secretase modulators directly bind to presenilin-1
    Journal Article

    Crump, C. J.; Fish, B. A.; Castro, S. V.; Chau, D. M.; Gestsik, N.; Ahn, K.; Stiff, C.; Pozdnyakov, N.; Bales, K. R.; Johnson, D. S.; more...
    ACS Chemical Neuroscience (2011)

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