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Christina J Crump

Formats
  1. Journal Article (10)
  2. Meeting Abstract (2)
Groups
  1. GSK Faculty (12)
  2. Molecular Pharmacology and Chemistry Program Faculty (12)
  3. Population Sciences Research Program (12)
  4. Sloan Kettering Institute Faculty (12)
  5. Adult Leukemia (1)
  6. Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center (1)

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People
  1. Yueming Li (12)
  2. Deming Chau (2)
  3. Kwangwook Ahn (2)
  4. Natalya Gestsik (2)
  5. Xianzhong Wu (2)
  6. David Scheinberg (1)

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Years
  1. 2020 (1)
  2. 2016 (1)
  3. 2013 (3)
  4. 2012 (4)
  5. 2011 (2)
  6. 2010 (1)
Publications
  1. Journal of Biological Chemistry (3)
  2. ACS Chemical Neuroscience (2)
  3. Biochemistry (2)
  4. Bioorganic & Medicinal Chemistry Letters (1)
  5. EMBO Journal (1)
  6. FASEB Journal (1)

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Publishers
  1. American Chemical Society (4)
  2. American Society for Biochemistry and Molecular Biology (3)
  3. Federation of American Societies for Experimental Biology (1)
  4. Nature Publishing Group (1)
  5. Pergamon-Elsevier Science Ltd (1)
  6. Society for Neuroscience (1)

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Results (12)

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  • The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
    Journal Article

    Hur, J. Y.; Frost, G. R.; Wu, X.; Crump, C.; Pan, S. J.; Wong, E.; Barros, M.; Li, T.; Nie, P.; Zhai, Y.; more...
    Nature (2020)

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  • Development of sulfonamide photoaffinity inhibitors for probing cellular γ-secretase
    Journal Article

    Crump, C. J.; Murrey, H. E.; Ballard, T. E.; am Ende, C. W.; Wu, X.; Gertsik, N.; Johnson, D. S.; Li, Y. M.
    ACS Chemical Neuroscience (2016)

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  • Clickable gamma-secretase modulator photoaffinity probes bind distinct sites on presenilin
    Meeting Abstract

    Murrey, H. E.; Pozdnyakov, N.; Crump, C. J.; Pettersson, M.; Li, Y. M.; Bales, K. R.; Johnson, D. S.
    FASEB Journal (2013)

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  • Development and mechanism of γ-secretase modulators for Alzheimer's disease
    Journal Article

    Crump, C. J.; Johnson, D. S.; Li, Y. M.
    Biochemistry (2013)

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  • γ-secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin
    Journal Article

    Pozdnyakov, N.; Murrey, H. E.; Crump, C. J.; Pettersson, M.; Ballard, T. E.; Am Ende, C. W.; Ahn, K.; Li, Y. M.; Bales, K. R.; Johnson, D. S.
    Journal of Biological Chemistry (2013)

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  • Determining the mechanism of gamma-secretase modulators
    Meeting Abstract

    Crump, C. J.; Johnson, D. S.; Bales, K. R.; Li, Y.
    Society for Neuroscience Abstract Viewer and Itinerary Planner (2012)

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  • BMS-708,163 targets presenilin and lacks notch-sparing activity
    Journal Article

    Crump, C. J.; Castro, S. V.; Wang, F.; Pozdnyakov, N.; Ballard, T. E.; Sisodia, S. S.; Bales, K. R.; Johnson, D. S.; Li, Y. M.
    Biochemistry (2012)

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  • Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase
    Journal Article

    Chau, D. M.; Crump, C. J.; Villa, J. C.; Scheinberg, D. A.; Li, Y. M.
    Journal of Biological Chemistry (2012)

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  • Development of clickable active site-directed photoaffinity probes for γ-secretase
    Journal Article

    Crump, C. J.; Am Ende, C. W.; Eric Ballard, T.; Pozdnyakov, N.; Pettersson, M.; Chau, D. M.; Bales, K. R.; Li, Y. M.; Johnson, D. S.
    Bioorganic & Medicinal Chemistry Letters (2012)

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  • Piperidine acetic acid based γ-secretase modulators directly bind to presenilin-1
    Journal Article

    Crump, C. J.; Fish, B. A.; Castro, S. V.; Chau, D. M.; Gestsik, N.; Ahn, K.; Stiff, C.; Pozdnyakov, N.; Bales, K. R.; Johnson, D. S.; more...
    ACS Chemical Neuroscience (2011)

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