Synapse - Gabriela Chiosis

Results (281)

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90

Journal Article

Gorre, M. E.; Ellwood-Yen, K.; Chiosis, G.; Rosen, N.; Sawyers, C. L.
Blood (2002)

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Development of a purine-scaffold novel class of hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

Journal Article

Chiosis, G.; Lucas, B.; Shtil, A.; Huezo, H.; Rosen, N.
Bioorganic & Medicinal Chemistry (2002)

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Journal Article

Basso, A. D.; Solit, D. B.; Chiosis, G.; Giri, B.; Tsichlis, P.; Rosen, N.
Journal of Biological Chemistry (2002)

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Synthesis and evaluation of a library of small molecules that degrade the HER2-tyrosine kinase

Meeting Abstract

Chiosis, G.; Lucas, B.; Timaul, M.; Rosen, N.
Proceedings of the American Association for Cancer Research Annual Meeting (2001)

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Development of 9-alkyl-8-benzyl-9H-purin-6-ylamines as inhibitors of the hsp90 family

Meeting Abstract

Chiosis, G.; Shtil, A.; Lucas, B.; Huezo, H.; Rosen, N.
Clinical Cancer Research (2001)

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A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells