LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family Journal Article


Authors: Chiosis, G.; Rosen, N.; Sepp-Lorenzino, L.
Article Title: LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family
Abstract: Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family. © 2001 Elsevier Science Ltd.
Keywords: unclassified drug; human cell; dna-binding proteins; drug activity; cell cycle proteins; enzyme inhibition; drug selectivity; drug synthesis; protein-serine-threonine kinases; tumor suppressor proteins; 1-phosphatidylinositol 3-kinase; chromones; morpholines; hsp90 heat-shock proteins; quinones; dimerization; inhibitory concentration 50; phosphotransferase inhibitor; benzoquinones; lactams, macrocyclic; 2 morpholino 8 phenylchromone; geldanamycin; dimer; heat shock protein 60; dna-activated protein kinase; human; article; phosphoinositol 3 kinase
Journal Title: Bioorganic & Medicinal Chemistry Letters
Volume: 11
Issue: 7
ISSN: 0960-894X
Publisher: Pergamon-Elsevier Science Ltd  
Date Published: 2001-04-09
Start Page: 909
End Page: 913
Language: English
DOI: 10.1016/s0960-894x(01)00099-3
PUBMED: 11294389
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Neal Rosen
    366 Rosen
  2. Gabriela Chiosis
    218 Chiosis