LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family Journal Article
| Authors: | Chiosis, G.; Rosen, N.; Sepp-Lorenzino, L. |
| Article Title: | LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family |
| Abstract: | Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family. © 2001 Elsevier Science Ltd. |
| Keywords: | unclassified drug; human cell; dna-binding proteins; drug activity; cell cycle proteins; enzyme inhibition; drug selectivity; drug synthesis; protein-serine-threonine kinases; tumor suppressor proteins; 1-phosphatidylinositol 3-kinase; chromones; morpholines; hsp90 heat-shock proteins; quinones; dimerization; inhibitory concentration 50; phosphotransferase inhibitor; benzoquinones; lactams, macrocyclic; 2 morpholino 8 phenylchromone; geldanamycin; dimer; heat shock protein 60; dna-activated protein kinase; human; article; phosphoinositol 3 kinase |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 11 |
| Issue: | 7 |
| ISSN: | 0960-894X |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2001-04-09 |
| Start Page: | 909 |
| End Page: | 913 |
| Language: | English |
| DOI: | 10.1016/s0960-894x(01)00099-3 |
| PUBMED: | 11294389 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
Altmetric Score
MSK Authors
Related MSK Work