Authors: | Chiosis, G.; Rosen, N.; Sepp-Lorenzino, L. |
Article Title: | LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family |
Abstract: | Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family. © 2001 Elsevier Science Ltd. |
Keywords: | unclassified drug; human cell; dna-binding proteins; drug activity; cell cycle proteins; enzyme inhibition; drug selectivity; drug synthesis; protein-serine-threonine kinases; tumor suppressor proteins; 1-phosphatidylinositol 3-kinase; chromones; morpholines; hsp90 heat-shock proteins; quinones; dimerization; inhibitory concentration 50; phosphotransferase inhibitor; benzoquinones; lactams, macrocyclic; 2 morpholino 8 phenylchromone; geldanamycin; dimer; heat shock protein 60; dna-activated protein kinase; human; article; phosphoinositol 3 kinase |
Journal Title: | Bioorganic & Medicinal Chemistry Letters |
Volume: | 11 |
Issue: | 7 |
ISSN: | 0960-894X |
Publisher: | Pergamon-Elsevier Science Ltd |
Date Published: | 2001-04-09 |
Start Page: | 909 |
End Page: | 913 |
Language: | English |
DOI: | 10.1016/s0960-894x(01)00099-3 |
PUBMED: | 11294389 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Export Date: 21 May 2015 -- Source: Scopus |