Overview of the relevance of PI3K pathway in HR-positive breast cancer Review
| Authors: | Vasan, N.; Toska, E.; Scaltriti, M. |
| Review Title: | Overview of the relevance of PI3K pathway in HR-positive breast cancer |
| Abstract: | One of the hallmarks of hormone receptor (HR)-positive breast cancer is its dependence on the phosphatidylinositol-3-kinase (PI3K) pathway. Here, we review the epidemiologic, functional, and pharmacologic interactions between oncogenic PI3K and the estrogen receptor (ER). We discuss the epidemiology of PI3K pathway alterations, mechanisms of resistance to PI3K inhibitors, and the current mechanistic landscape of crosstalk between PI3K and ER, which provide the rationale for dual ER and PI3K inhibition and is now a standard of care in the treatment of ER+ PIK3CA-mutant metastatic breast cancer. We outline newer studies in this field that delineate the clinically relevant overlaps between PI3K and parallel signaling pathways, insulin signaling, and ER epigenetic modifiers. We also identify several caveats with the current data and propose new strategies to overcome these bottlenecks. © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology. |
| Keywords: | breast cancer; estrogen receptor; akt; pik3ca; pi3k pathway; pi3k inhibitors |
| Journal Title: | Annals of Oncology |
| Volume: | 30 |
| Issue: | Suppl. 10 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2019-12-01 |
| Start Page: | x3 |
| End Page: | x11 |
| Language: | English |
| DOI: | 10.1093/annonc/mdz281 |
| PUBMED: | 31859348 |
| PROVIDER: | scopus |
| PMCID: | PMC6923788 |
| DOI/URL: | |
| Notes: | Corrigendum issued, see DOI; 10.1016/j.annonc.2020.01.067 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work