Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer Review

   

Authors:	Castel, P.; Toska, E.
Review Title:	Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer
Abstract:	Estrogen Receptor (ER) and the phosphoinositide 3-kinase (PI3K) pathways participate in regulatory crosstalk in breast cancer. We identified that chromatin regulation is at the intersection of oncogenic PI3K and ER. The PI3K effectors AKT, also known as protein kinase B (PKB), and SGK (serum/glucocorticoid-regulated kinase) play a redundant role by phosphorylating the chromatin regulator KMT2D and modulating ER activity and therapy resistance. © 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.
Keywords:	survival; protein kinase b; treatment response; cancer growth; cell proliferation; cell survival; progression free survival; breast cancer; hepatocyte nuclear factor 3alpha; transcription factor gata 3; estrogen responsive element; cell growth; transcription initiation; protein tyrosine kinase; phosphorylation; phosphatidylinositol 3 kinase; exemestane; transcription regulation; chromatin; tuberin; tamoxifen; dimerization; therapy resistance; upregulation; feedback system; letrozole; estrogen receptor; metastatic breast cancer; protein p110; serum and glucocorticoid regulated kinase 1; phosphatidylinositol 3,4,5 trisphosphate; fulvestrant; gene activity; transcription initiation site; phosphoinositide dependent protein kinase 1; phosphatidylinositol 3 kinase inhibitor; histone lysine methyltransferase; mammalian target of rapamycin complex 1; receptor cross-talk; chromatin regulation; pi3k pathway; pi3k/akt signaling; sgk1; phosphatidylinositol 4,5 bisphosphate; gene knockdown; human; article; pi3k inhibitors; alpelisib; akt1; estrogen receptor antagonist; kmt2d; mrna expression level; protein expression level; pre b cell leukemia transcription factor 1
Journal Title:	Molecular and Cellular Oncology
Volume:	6
Issue:	6
ISSN:	2372-3556
Publisher:	Taylor & Francis Group
Date Published:	2019-01-01
Start Page:	e1625620
Language:	English
DOI:	10.1080/23723556.2019.1625620
PROVIDER:	scopus
PMCID:	PMC6816426
PUBMED:	31692833
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071717081&doi=10.1080%2f23723556.2019.1625620&partnerID=40&md5=88a91392b5f391343d837fcc333a850c
Notes:	Article -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/156908