Research Focus

Former Employee. SKI Pediatrics; Research Asst, Sr

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1. Human lymphocytes sensitized to HLA A0201 and HLA A2402 binding WT-1 peptides loaded on autologous cytokine activated monocytes or EBV transformed B cells yield HLA restricted WT-1 peptide specific cytotoxic T cells that lyse primary WT-1+leukemic cells in vitro and, in vivo, home to and induced regression of WT-1+leukemic xenografts bearing the restricting HLA alleles

   Meeting Abstract

   Doubrovina, E.; Guerrero, J.; Lee, S. Y.; Koehne, G.; Doubrovin, M.; Diaz-Barrientos, T.; O'Reilly, R. J.
   Blood (2002)

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2. Preparative cytoreduction and chimeric state influence HLA restriction patterns of virus specific donor T cells developing late after HLA A, B, DR haplotype disparate T cell depleted (TCD) marrow transplant for severe combined immunodeficiency (SCID)

   Meeting Abstract

   Doubrovina, E. S.; Koulova, L.; Kersten, M. J.; Sokolona, E.; Guerrero, J.; Diaz-Barrientos, T.; O'Reilly, R. J.
   Blood (2002)

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3. Correction of defective expression in MHC class II deficiency (bare lymphocyte syndrome) cells by retroviral transduction of CIITA

   Journal Article

   Bradley, M. B.; Fernandez, J. M.; Ungers, G.; Diaz-Barrientos, T.; Steimle, V.; Mach, B.; O'Reilly, R.; Lee, J. S.
   Journal of Immunology (1997)

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