Synapse - Darren Veach

Results (99)

Two distinct phosphorylation pathways have additive effects on Abl family kinase activation

Journal Article

Tanis, K. Q.; Veach, D.; Duewel, H. S.; Bornmann, W. G.; Koleske, A. J.
Molecular and Cellular Biology (2003)

A fluorine-labeled methotrexate as a probe for monitoring tumor antifolate pharmacokinetics: Synthesis, in vitro cytotoxicity, and pilot in vivo (19)F magnetic resonance spectra

Journal Article

Spees, W. M.; Yang, G.; Veach, D.; Rubio, M. B.; Koutcher, J. A.; Bornmann, W.
Molecular Cancer Therapeutics (2003)

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Gleevec inhibits β-amyloid production but not Notch cleavage

Journal Article

Netzer, W. J.; Dou, F.; Cai, D.; Veach, D.; Jean, S.; Li, Y.; Bornmann, W. G.; Clarkson, B.; Xu, H.; Greengard, P.
Proceedings of the National Academy of Sciences of the United States of America (2003)

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

Journal Article

Nagar, B.; Hantschel, O.; Young, M. A.; Scheffzek, K.; Veach, D.; Bornmann, W.; Clarkson, B.; Superti-Furga, G.; Kuriyan, J.
Cell (2003)

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Towards picomolar inhibition of Bcr-Abl: Synthesis and evaluation of a focused library of pyrido-(2,3-d)-pyrimidine tyrosine kinase inhibitors guided by x-ray crystallography and molecular modeling

Meeting Abstract

Veach, D. R.; Swendeman, S.; Nagar, B.; Wisniewski, D.; Strife, A.; Lambek, C. L.; Liu, C.; Lee, W.; Bornmann, W.; Kuriyan, J.; more...
Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

Journal Article

Nagar, B.; Bornmann, W. G.; Pellicena, P.; Schindler, T.; Veach, D. R.; Miller, W. T.; Clarkson, B.; Kuriyan, J.
Cancer Research (2002)

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Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases

Journal Article

Wisniewski, D.; Lambek, C. L.; Liu, C.; Strife, A.; Veach, D. R.; Nagar, B.; Young, M. A.; Schindler, T.; Bornmann, W. G.; Bertino, J. R.; more...
Cancer Research (2002)

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Crystal structures of the c-Abl tyrosine kinase domain in complex with STI-571 and a novel Bcr-Abl inhibitor, PD173955

Meeting Abstract

Swendeman, S.; Nagar, B.; Wisniewski, D.; Strife, A.; Lambek, C.; Liu, C.; Veach, D.; Bornmann, W.; Kuriyan, J.; Clarkson, B.
Clinical Cancer Research (2001)

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Fluorescent monitoring of kinase activity in real time: Development of a robust fluorescence-based assay for Abl tyrosine kinase activity

Journal Article

Hofmann, R. M.; Cotton, G. J.; Chang, E. J.; Vidal, E.; Veach, D.; Bornmann, W.; Muir, T. W.
Bioorganic & Medicinal Chemistry Letters (2001)

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