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Research Focus

Former Employee. MOLECULAR BIOLOGY; Research Fellow

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1. The SMC5/6 complex exhibits dynamic binding on double-stranded DNA, but binds stably to branched DNA

   Meeting Abstract

   Chang, J. T.; Li, S.; Beckwitt, E.; Than, T.; Haluska, C.; Chandanani, J.; O'Donnell, M.; Zhao, X.; Liu, S.
   Biophysical Journal (2023)

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2. Smc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures

   Journal Article

   Chang, J. T. H.; Li, S.; Beckwitt, E. C.; Than, T.; Haluska, C.; Chandanani, J.; O’Donnell, M. E.; Zhao, X.; Liu, S.
   Nature Communications (2022)

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3. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes

   Journal Article

   Yu, Y.; Li, S.; Ser, Z.; Kuang, H.; Than, T.; Guan, D.; Zhao, X.; Patel, D. J.
   Proceedings of the National Academy of Sciences of the United States of America (2022)

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