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Fuzhong F Zheng

Formats
  1. Meeting Abstract (6)
  2. Journal Article (5)
Groups
  1. Breast Medicine Service (11)
  2. Department of Medicine (11)
  3. GSK Faculty (11)
  4. Molecular Pharmacology and Chemistry Program Faculty (11)
  5. Sloan Kettering Institute Faculty (11)
  6. Solid Tumor Oncology Division (11)

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People
  1. Neal Rosen (11)
  2. Laura Sepp-Lorenzino (8)
  3. Pamela Munster (7)
  4. Samuel Danishefsky (6)
  5. Scott Kuduk (5)
  6. Gabriela Chiosis (4)

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Years
  1. 2002 (2)
  2. 2001 (1)
  3. 2000 (4)
  4. 1999 (4)
Publications
  1. Clinical Cancer Research (5)
  2. Bioorganic & Medicinal Chemistry Letters (2)
  3. Proceedings of the American Association for Cancer Research Annual Meeting (2)
  4. Cancer Research (1)
  5. Chemistry and Biology (1)
Publishers
  1. American Association for Cancer Research (8)
  2. Pergamon-Elsevier Science Ltd (2)
  3. Elsevier Inc. (1)

Results (11)

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  • G1 arrest of prostate cancer cells by antiandrogens is associated with reduction of Skp2 expression and rapid p27-independent loss in cyclin E-associated kinase activity
    Meeting Abstract

    Zheng, F.; Lobo, J.; Solit, D.; Rosen, N.; Scher, H.
    Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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  • 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
    Journal Article

    Solit, D. B.; Zheng, F. F.; Drobnjak, M.; Münster, P. N.; Higgins, B.; Verbel, D.; Heller, G.; Tong, W.; Cordon-Cardo, C.; Agus, D. B.; more...
    Clinical Cancer Research (2002)

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  • A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
    Journal Article

    Chiosis, G.; Timaul, M. N.; Lucas, B.; Munster, P. N.; Zheng, F. F.; Sepp-Lorenzino, L.; Rosen, N.
    Chemistry and Biology (2001)

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  • Development of targeted ansamycins as novel anti-steroid agents and tyrosine kinase inhibitors in the treatment of breast and prostate cancers
    Meeting Abstract

    Zheng, F. F.; Kuduk, S. D.; Munster, P. N.; Chiosis, G.; Sepp-Lorenzino, L.; Danishefsky, S. J.; Rosen, N.
    Clinical Cancer Research (2000)

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  • Design and synthesis of small molecule inhibitors of the Hsp90 chaperone
    Meeting Abstract

    Chiosis, G.; Timaul, M. N.; Sepp-Lorenzino, L.; Zheng, F. Z. F.; Lucas, B.; Danishefsky, S. J.; Rosen, N.
    Clinical Cancer Research (2000)

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  • Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases
    Journal Article

    Zheng, F. F.; Kuduk, S. D.; Chiosis, G.; Münster, P. N.; Sepp-Lorenzino, L.; Danishefsky, S. J.; Rosen, N.
    Cancer Research (2000)

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  • Synthesis and evaluation of geldanamycin-testosterone hybrids
    Journal Article

    Kuduk, S. D.; Harris, C. R.; Zheng, F. F.; Sepp-Lorenzino, L.; Ouerfelli, O.; Rosen, N.; Danishefsky, S. J.
    Bioorganic & Medicinal Chemistry Letters (2000)

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  • Inductin of differentiation and apoptosis in human breast cancer cell lines by the modified geldanamycin (17-AAG)
    Meeting Abstract

    Münster, P. N.; Zheng, F. F.; Sepp-Lorenzino, L.; Sausville, E. A.; Rosen, N.
    Proceedings of the American Association for Cancer Research Annual Meeting (1999)

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  • The Hsp90 chaperone system as a potential therapeutic target: Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases
    Meeting Abstract

    Zheng, F. Z. F.; Münster, P. N.; Kuduk, S.; Danishefsky, S.; Sepp-Lorenzino, L.; Rosen, N.
    Clinical Cancer Research (1999)

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  • Induction of differentiation and apoptosis in human breast cancer cell lines by modified geldanamycin derivatives (17-AAG)
    Meeting Abstract

    Münster, P. N.; Zheng, F. F.; Srethapakdi, M.; Sausville, E.; Rosen, N.
    Clinical Cancer Research (1999)

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