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Li-Kai Wang

Formats
  1. Journal Article (26)
  2. Meeting Abstract (1)
Groups
  1. Basic Research Innovation Award (BRIA) (25)
  2. GSK Faculty (25)
  3. Molecular Biology Program Faculty (25)
  4. Sloan Kettering Institute Faculty (25)
  5. Center for Molecular Imaging and Biotechnology (2)
  6. Department of Medicine (2)

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People
  1. Stewart Shuman (25)
  2. Paul Smith (7)
  3. Hui Zhu (4)
  4. Ushati Das (4)
  5. Chong-Kiong Ho (2)
  6. Christopher Lima (2)

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Years
  1. 2014 (2)
  2. 2013 (2)
  3. 2012 (2)
  4. 2010 (1)
  5. 2009 (1)
  6. 2008 (1)

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Publications
  1. Journal of Biological Chemistry (6)
  2. Nucleic Acids Research (5)
  3. RNA (4)
  4. Biochemistry (3)
  5. Proceedings of the National Academy of Sciences of the United States of America (2)
  6. Cell (1)

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Publishers
  1. American Society for Biochemistry and Molecular Biology (6)
  2. Oxford University Press (5)
  3. Cold Spring Harbor Laboratory Press (4)
  4. American Chemical Society (3)
  5. Cell Press (2)
  6. National Academy of Sciences (2)

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Results (27)

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  • Structures of bacterial polynucleotide kinase in a Michaelis complex with nucleoside triphosphate (NTP)-Mg2+ and 5'-OH RNA and a mixed substrate-product complex with NTP-Mg2+ and a 5'-phosphorylated oligonucleotide
    Journal Article

    Das, U.; Wang, L. K.; Smith, P.; Munir, A.; Shuman, S.
    Journal of Bacteriology (2014)

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  • Structures of bacterial polynucleotide kinase in a Michaelis complex with GTPMg2+ and 5′-OH oligonucleotide and a product complex with GDPMg2+ and 5′-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition
    Journal Article

    Das, U.; Wang, L. K.; Smith, P.; Jacewicz, A.; Shuman, S.
    Nucleic Acids Research (2014)

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  • Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial Pnkp•Hen1 RNA repair system
    Journal Article

    Das, U.; Wang, L. K.; Smith, P.; Shuman, S.
    Biochemistry (2013)

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  • Structure and mechanism of the 2′,3′ phosphatase component of the bacterial Pnkp-Hen1 RNA repair system
    Journal Article

    Wang, L. K.; Smith, P.; Shuman, S.
    Nucleic Acids Research (2013)

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  • Structure and mechanism of the polynucleotide kinase component of the bacterial Pnkp-Hen1 RNA repair system
    Journal Article

    Wang, L. K.; Das, U.; Smith, P.; Shuman, S.
    RNA (2012)

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  • The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family
    Journal Article

    Smith, P.; Wang, L. K.; Nair, P. A.; Shuman, S.
    Proceedings of the National Academy of Sciences of the United States of America (2012)

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  • Mutational analysis of the 5'-OH oligonucleotide phosphate acceptor site of T4 polynucleotide kinase
    Journal Article

    Wang, L. K.; Shuman, S.
    Nucleic Acids Research (2010)

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  • Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli DNA Ligase (LigA)
    Journal Article

    Wang, L. K.; Zhu, H.; Shuman, S.
    Journal of Biological Chemistry (2009)

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  • Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase
    Journal Article

    Wang, L. K.; Nair, P. A.; Shuman, S.
    Journal of Biological Chemistry (2008)

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  • Structure-function analysis of the 3′ phosphatase component of T4 polynucleotide kinase/phosphatase
    Journal Article

    Zhu, H.; Smith, P.; Wang, L. K.; Shuman, S.
    Virology (2007)

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