Synapse - Li-Kai Wang

Li-Kai Wang

Research Focus

Former Employee. Molecular Biology; Senior Research Scientist

Recent additions – View all

Structures of bacterial polynucleotide kinase in a Michaelis complex with nucleoside triphosphate (NTP)-Mg2+ and 5'-OH RNA and a mixed substrate-product complex with NTP-Mg2+ and a 5'-phosphorylated oligonucleotide
Journal Article

Das, U.; Wang, L. K.; Smith, P.; Munir, A.; Shuman, S.
Journal of Bacteriology (2014)

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Structures of bacterial polynucleotide kinase in a Michaelis complex with GTPMg2+ and 5′-OH oligonucleotide and a product complex with GDPMg2+ and 5′-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition
Journal Article

Das, U.; Wang, L. K.; Smith, P.; Jacewicz, A.; Shuman, S.
Nucleic Acids Research (2014)

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Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial Pnkp•Hen1 RNA repair system
Journal Article

Das, U.; Wang, L. K.; Smith, P.; Shuman, S.
Biochemistry (2013)

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Co-authors at MSK

25

Shuman
7

Smith
4

Das
4

Zhu
2

Ho
2

Lima
2

Nair
2

Nandakumar
1

Abou-Alfa
1

Aniukwu
1

Colville
1

Glickman
1

Jacewicz
1

Kalaigian
1

Liu
1

Munir
1

Pei
1

Saltz
1

Schwartz
1

Sekiguchi
1

Zhao

Types of Work

Publications

Journal of Biological Chemistry (6)
Nucleic Acids Research (5)
RNA (4)
Biochemistry (3)
Proceedings of the National Academy of Sciences of the United States of America (2)
Cell (1)
EMBO Journal (1)
Journal of Bacteriology (1)
Journal of Clinical Oncology (1)
Protein Science (1)