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Amanda Joy Hunkele

Formats
  1. Journal Article (18)
Groups
  1. Molecular Pharmacology and Chemistry Program Faculty (16)
  2. Sloan Kettering Institute Faculty (16)
  3. Sloan Kettering Institute Postdocs (7)
  4. Anesthesiology Service (2)
  5. Anesthesiology and Critical Care Medicine (2)
People
  1. Gavril Pasternak (16)
  2. Valerie Le Rouzic (12)
  3. Yingxian Pan (12)
  4. Susruta Majumdar (10)
  5. Jin Xu (9)
  6. Joan Subrath (6)

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Years
  1. 2025 (1)
  2. 2024 (1)
  3. 2021 (6)
  4. 2019 (3)
  5. 2018 (1)
  6. 2017 (2)

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Publications
  1. ACS Chemical Neuroscience (5)
  2. Cellular and Molecular Neurobiology (2)
  3. Journal of Medicinal Chemistry (2)
  4. Nature Communications (2)
  5. Anesthesia and Analgesia (1)
  6. Journal of Clinical Investigation (1)

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Publishers
  1. American Chemical Society (7)
  2. Nature Publishing Group (2)
  3. Springer (2)
  4. American Society for Clinical Investigation (1)
  5. Lippincott Williams & Wilkins (1)
  6. Pergamon-Elsevier Science Ltd (1)

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Results (18)


Citation style sort is year ascending, and then by author or title. Author ascending is default.
  • Synthesis and pharmacology of a morphinan-derived dual Mu−Kappa opioid receptor agonist analgesic
    Journal Article

    Varga, B. R.; Uprety, R.; Paul, B.; Knoll, A.; Ramos-Gonzalez, N.; Appourchaux, K.; Taylor, T.; Turgutalp, B.; Shinouchi, R.; Eans, S. O.; more...
    ACS Chemical Neuroscience (2025)

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  • Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
    Journal Article

    Havel, V.; Kruegel, A. C.; Bechand, B.; McIntosh, S.; Stallings, L.; Hodges, A.; Wulf, M. G.; Nelson, M.; Hunkele, A.; Ansonoff, M.; more...
    Nature Communications (2024)

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  • Oxidative metabolism as a modulator of kratom's biological actions
    Journal Article

    Chakraborty, S.; Uprety, R.; Slocum, S. T.; Irie, T.; Le Rouzic, V.; Li, X.; Wilson, L. L.; Scouller, B.; Alder, A. F.; Kruegel, A. C.; more...
    Journal of Medicinal Chemistry (2021)

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  • Kratom alkaloids as probes for opioid receptor function: Pharmacological characterization of minor indole and oxindole alkaloids from kratom
    Journal Article

    Chakraborty, S.; Uprety, R.; Daibani, A. E.; Rouzic, V. L.; Hunkele, A.; Appourchaux, K.; Eans, S. O.; Nuthikattu, N.; Jilakara, R.; Thammavong, L.; more...
    ACS Chemical Neuroscience (2021)

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  • Synthesis and characterization of azido aryl analogs of IBNtxA for radio-photoaffinity labeling opioid receptors in cell lines and in mouse brain
    Journal Article

    Grinnell, S. G.; Uprety, R.; Varadi, A.; Subrath, J.; Hunkele, A.; Pan, Y. X.; Pasternak, G. W.; Majumdar, S.
    Cellular and Molecular Neurobiology (2021)

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  • Mu opioids induce biased signaling at the full-length seven transmembrane C-terminal splice variants of the mu opioid receptor gene, Oprm1
    Journal Article

    Narayan, A.; Hunkele, A.; Xu, J.; Bassoni, D. L.; Pasternak, G. W.; Pan, Y. X.
    Cellular and Molecular Neurobiology (2021)

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  • Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
    Journal Article

    Bhowmik, S.; Galeta, J.; Havel, V.; Nelson, M.; Faouzi, A.; Bechand, B.; Ansonoff, M.; Fiala, T.; Hunkele, A.; Kruegel, A. C.; more...
    Nature Communications (2021)

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  • Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
    Journal Article

    Uprety, R.; Che, T.; Zaidi, S. A.; Grinnell, S. G.; Varga, B. R.; Faouzi, A.; Slocum, S. T.; Allaoa, A.; Varadi, A.; Nelson, M.; more...
    eLife (2021)

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  • Identification of abundant and evolutionarily conserved opioid receptor circular RNAs in the nervous system modulated by morphine
    Journal Article

    Irie, T.; Shum, R.; Deni, I.; Hunkele, A.; Le Rouzic, V.; Xu, J.; Wilson, R.; Fischer, G. W.; Pasternak, G. W.; Pan, Y. X.
    Molecular Pharmacology (2019)

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  • Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis
    Journal Article

    Hu, X.; Wang, Y.; Hunkele, A.; Provasi, D.; Pasternak, G. W.; Filizola, M.
    PLoS Computational Biology (2019)

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