Synapse - Roger Smith

Results (20)

Combination of MDM2 and targeted kinase inhibitors results in prolonged tumor control in lung adenocarcinomas with oncogenic tyrosine kinase drivers and MDM2 amplification

Journal Article

Elkrief, A.; Odintsov, I.; Smith, R. S.; Vojnic, M.; Hayashi, T.; Khodos, I.; Markov, V.; Liu, Z.; Lui, A. J. W.; Bloom, J. L.; more...
JCO Precision Oncology (2024)

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Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling

Journal Article

Smith, R. S.; Odintsov, I.; Liu, Z.; Lui, A. J. W.; Hayashi, T.; Vojnic, M.; Suehara, Y.; Delasos, L.; Mattar, M. S.; Hmeljak, J.; more...
Disease Models & Mechanisms (2022)

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RET inhibition in novel patient-derived models of RET fusion-positive lung adenocarcinoma reveals a role for MYC upregulation

Journal Article

Hayashi, T.; Odintsov, I.; Smith, R. S.; Ishizawa, K.; Liu, A. J. W.; Delasos, L.; Kurzatkowski, C.; Tai, H.; Gladstone, E.; Vojnic, M.; more...
Disease Models & Mechanisms (2021)

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Activation of KRAS mediates resistance to targeted therapy in MET exon 14–mutant non–small cell lung cancer

Journal Article

Suzawa, K.; Offin, M.; Lu, D.; Kurzatkowski, C.; Vojnic, M.; Smith, R. S.; Sabari, J. K.; Tai, H.; Mattar, M.; Khodos, I.; more...
Clinical Cancer Research (2019)

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Oncogenic KRAS mediates resistance to MET targeted therapy in non-small cell lung cancer (NSCLC) with MET mutations that induce exon14 skipping

Meeting Abstract

Suzawa, K.; Offin, M. D.; Kurzatkowski, C.; Liu, D.; Vojnic, M.; Smith, R. S.; Mattar, M.; Khodos, I.; de Stanchina, E.; Sabari, J. K.; more...
Cancer Research (2018)

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RASA1 and NF1 are preferentially co-mutated and define a distinct genetic subset of smoking-associated non–small cell lung carcinomas sensitive to MEK inhibition