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Brian Lucas

Formats
  1. Journal Article (5)
  2. Meeting Abstract (4)
Groups
  1. Breast Medicine Service (9)
  2. Center for Hematologic Malignancies (9)
  3. Department of Medicine (9)
  4. GSK Faculty (9)
  5. Hematologic Malignancies Research (9)
  6. Molecular Pharmacology and Chemistry Program Faculty (9)

More Groups

People
  1. Gabriela Chiosis (9)
  2. Neal Rosen (9)
  3. Henri Huezo (4)
  4. Neilawattie Torres (3)
  5. Alexander Shtil (2)
  6. Andrea Basso (2)

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Years
  1. 2004 (1)
  2. 2003 (1)
  3. 2002 (2)
  4. 2001 (4)
  5. 2000 (1)
Publications
  1. Chemistry and Biology (2)
  2. Clinical Cancer Research (2)
  3. Abstracts of Papers of the American Chemical Society (1)
  4. Bioorganic & Medicinal Chemistry (1)
  5. Current Cancer Drug Targets (1)
  6. Journal of Combinatorial Chemistry (1)

More Publications

Publishers
  1. American Association for Cancer Research (3)
  2. American Chemical Society (2)
  3. Elsevier Inc. (2)
  4. Bentham Science Publishers (1)
  5. Pergamon-Elsevier Science Ltd (1)

Results (9)

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  • Targeting wide-range oncogenic transformation via PU24FCI, a specific inhibitor of tumor Hsp90
    Journal Article

    Vilenchik, M.; Solit, D.; Basso, A.; Huezo, H.; Lucas, B.; He, H.; Rosen, N.; Spampinato, C.; Modrich, P.; Chiosis, G.
    Chemistry and Biology (2004)

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  • Development of purine-scaffold small molecule inhibitors of Hsp90
    Journal Article

    Chiosis, G.; Lucas, B.; Huezo, H.; Solit, D.; Basso, A.; Rosen, N.
    Current Cancer Drug Targets (2003)

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  • Development of novel hsp90 inhibitors as cancer therapeutics
    Meeting Abstract

    Chiosis, G.; Rosen, N.; Lucas, B.
    Abstracts of Papers of the American Chemical Society (2002)

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  • Development of a purine-scaffold novel class of hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
    Journal Article

    Chiosis, G.; Lucas, B.; Shtil, A.; Huezo, H.; Rosen, N.
    Bioorganic & Medicinal Chemistry (2002)

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  • Synthesis and evaluation of a library of small molecules that degrade the HER2-tyrosine kinase
    Meeting Abstract

    Chiosis, G.; Lucas, B.; Timaul, M.; Rosen, N.
    Proceedings of the American Association for Cancer Research Annual Meeting (2001)

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  • Development of 9-alkyl-8-benzyl-9H-purin-6-ylamines as inhibitors of the hsp90 family
    Meeting Abstract

    Chiosis, G.; Shtil, A.; Lucas, B.; Huezo, H.; Rosen, N.
    Clinical Cancer Research (2001)

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  • A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
    Journal Article

    Chiosis, G.; Timaul, M. N.; Lucas, B.; Munster, P. N.; Zheng, F. F.; Sepp-Lorenzino, L.; Rosen, N.
    Chemistry and Biology (2001)

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  • Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives
    Journal Article

    Lucas, B.; Rosen, N.; Chiosis, G.
    Journal of Combinatorial Chemistry (2001)

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  • Design and synthesis of small molecule inhibitors of the Hsp90 chaperone
    Meeting Abstract

    Chiosis, G.; Timaul, M. N.; Sepp-Lorenzino, L.; Zheng, F. Z. F.; Lucas, B.; Danishefsky, S. J.; Rosen, N.
    Clinical Cancer Research (2000)

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