Erectile dysfunction Journal Article

   


Authors: Yafi, F. A.; Jenkins, L.; Albersen, M.; Corona, G.; Isidori, A.; Goldfarb, S.; Maggi, M.; Nelson, C. J.; Parish, S.; Salonia, A.; Tan, R.; Mulhall, J. P.; Hellstrom, W. J. G.
Article Title: Erectile dysfunction
Abstract: Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man's quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner's sexual experience and the couple's quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.
Keywords: prosthesis; cavernous nerve injury; placebo-controlled trial; quality-of-life; term-follow-up; male sexual dysfunction; urinary-tract symptoms; standard operating procedures; inflatable penile; serum testosterone levels; rat corpus cavernosum
Journal Title: Nature Reviews Disease Primers
Volume: 2
ISSN: 2056-676X
Publisher: Nature Publishing Group  
Date Published: 2016-02-04
Start Page: 16003
Language: English
ACCESSION: WOS:000381355700001
DOI: 10.1038/nrdp.2016.3
PROVIDER: wos
PMCID: PMC5027992
PUBMED: 27188339
Notes: Article -- 16003 -- Source: Wos
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MSK Authors
  1. John P Mulhall
    601 Mulhall
  2. Lawrence Calvin Jenkins II
    63 Jenkins II
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