Pancreatic cancer biology and genetics from an evolutionary perspective Journal Article
| Authors: | Makohon-Moore, A.; Iacobuzio-Donahue, C. A. |
| Article Title: | Pancreatic cancer biology and genetics from an evolutionary perspective |
| Abstract: | Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma ( hereafter referred to as pancreatic cancer) is a particularly robust example of this phenomenon. Genomic features indicate that pancreatic cancer cells are selected for fitness advantages when encountering the geographic and resource-depleted constraints of the microenvironment. Phenotypic adaptations to these pressures help disseminated cells to survive in secondary sites, a major clinical problem for patients with this disease. In this Review we gather the wide-ranging aspects of pancreatic cancer research into a single concept rooted in Darwinian evolution, with the goal of identifying novel insights and opportunities for study. |
| Keywords: | therapeutic targets; genome-wide association; susceptibility; stellate cells; tumor-suppressor gene; tgf-beta; loci; intraepithelial neoplasia; ductal adenocarcinoma; clonal evolution; oncogenic ras |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 16 |
| Issue: | 9 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2016-09-01 |
| Start Page: | 553 |
| End Page: | 565 |
| Language: | English |
| ACCESSION: | WOS:000382306000004 |
| DOI: | 10.1038/nrc.2016.66 |
| PROVIDER: | wos |
| PUBMED: | 27444064 |
| PMCID: | PMC5739515 |
| Notes: | Review -- Source: Wos |
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