Precancerous neoplastic cells can move through the pancreatic ductal system Journal Article


Authors: Makohon-Moore, A. P.; Matsukuma, K.; Zhang, M.; Reiter, J. G.; Gerold, J. M.; Jiao, Y.; Sikkema, L.; Attiyeh, M. A.; Yachida, S.; Sandone, C.; Hruban, R. H.; Klimstra, D. S.; Papadopoulos, N.; Nowak, M. A.; Kinzler, K. W.; Vogelstein, B.; Iacobuzio-Donahue, C. A.
Article Title: Precancerous neoplastic cells can move through the pancreatic ductal system
Abstract: Most adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. However, the evolutionary and genetic relationships among co-existing lesions are unclear. Here we analysed the somatic variants of pancreatic cancers and precursor lesions sampled from distinct regions of the same pancreas. After inferring evolutionary relationships, we found that the ancestral cell had initiated and clonally expanded to form one or more lesions, and that subsequent driver gene mutations eventually led to invasive pancreatic cancer. We estimate that this multi-step progression generally spans many years. These new data reframe the step-wise progression model of pancreatic cancer by illustrating that independent, high-grade pancreatic precursor lesions observed in a single pancreas often represent a single neoplasm that has colonized the ductal system, accumulating spatial and genetic divergence over time. © 2018, Springer Nature Limited.
Journal Title: Nature
Volume: 561
Issue: 7722
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 2018-09-13
Start Page: 201
End Page: 205
Language: English
DOI: 10.1038/s41586-018-0481-8
PROVIDER: scopus
PUBMED: 30177826
DOI/URL:
Notes: Article -- Export Date: 1 October 2018 -- Source: Scopus
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