Clostridium difficile colitis: Pathogenesis and host defence Journal Article
| Authors: | Abt, M. C.; McKenney, P. T.; Pamer, E. G. |
| Article Title: | Clostridium difficile colitis: Pathogenesis and host defence |
| Abstract: | Clostridium difficile is a major cause of intestinal infection and diarrhoea in individuals following antibiotic treatment. Recent studies have begun to elucidate the mechanisms that induce spore formation and germination and have determined the roles of C. difficile toxins in disease pathogenesis. Exciting progress has also been made in defining the role of the microbiome, specific commensal bacterial species and host immunity in defence against infection with C. difficile. This Review will summarize the recent discoveries and developments in our understanding of C. difficile infection and pathogenesis. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. |
| Journal Title: | Nature Reviews Microbiology |
| Volume: | 14 |
| Issue: | 10 |
| ISSN: | 1740-1526 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2016-10-01 |
| Start Page: | 609 |
| End Page: | 620 |
| Language: | English |
| DOI: | 10.1038/nrmicro.2016.108 |
| PROVIDER: | scopus |
| PUBMED: | 27573580 |
| PMCID: | PMC5109054 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 October 2016 -- Source: Scopus |
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