Low energy cyclotron production and separation of yttrium-86 for evaluation of monoclonal antibody pharmacokinetics and dosimetry Conference Paper
| Authors: | Finn, R. D.; McDevitt, M.; Ma, D.; Jurcic, J.; Scheinberg, D.; Larson, S.; Shoner, S.; Link, J.; Krohn, K.; Schlyer, D. |
| Editors: | Duggan, J. L.; Stippec, B.; Morgan, I. L. |
| Title: | Low energy cyclotron production and separation of yttrium-86 for evaluation of monoclonal antibody pharmacokinetics and dosimetry |
| Conference Title: | 15th International Conference on the Application of Accelerators in Research and Industry |
| Abstract: | Although an excellent radionuclide for application to systemic isotopic therapy when complexed to various monoclonal antibodies, the lack of photon emission from yttrium-90 makes the determination of the pharmacokinetics and dosimetry of the resultant radiopharmaceutical difficult. The introduction of the positron-emitting radionuclide yttrium-86 (T-1/2 = 14.7 h, beta(+) = 33%) provides the non-invasive quantitation for the biodistribution of the chelated complex. The yttrium-86 radionuclide is produced at Memorial Sloan-Kettering using the CS-15 cyclotron via the (p,n) nuclear reaction on an enriched strontium-86 target. The separation is effectively achieved through a combination of solvent extraction and ion exchange chromatography. Once investigational new drug approval has been received, the mixed nuclides, Y-90 and Y-86, are to be used to formulate the HuM195 labeled monoclonal antibody, a radiopharmaceutical under active investigation against hematopoietic progenitor cells. |
| Journal Title | AIP Conference Proceedings |
| Volume: | 475 |
| Conference Dates: | 1998 Nov 4-7 |
| Conference Location: | Denton, TX |
| ISBN: | 0094-243X |
| Publisher: | American Institute of Physics |
| Date Published: | 1999-06-10 |
| Start Page: | 991 |
| End Page: | 993 |
| Language: | English |
| ACCESSION: | WOS:000081503200237 |
| PROVIDER: | wos |
| DOI: | 10.1063/1.59302 |
| Notes: | Proceedings Paper -- Source: Wos |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work