Production and quality assurance of cyclotron produced iodine-124 from enriched tellurium targets Conference Paper
| Authors: | Balatoni, J.; Finn, R.; Blasberg, R.; Tjuvajev, J.; Larson, S. |
| Editors: | Duggan, J. L.; Stippec, B.; Morgan, I. L. |
| Title: | Production and quality assurance of cyclotron produced iodine-124 from enriched tellurium targets |
| Conference Title: | 15th International Conference on the Application of Accelerators in Research and Industry |
| Abstract: | The production of iodine-124 and the formulation of specific radiopharmaceuticals are an important component of the Positron Emission Tomography Program at Memorial Sloan-Kettering Cancer Center; Preparation of iodine-124 using the CS-15 cyclotron employing the (p, n) nuclear reaction on an enriched (TeO2)-Te-124 solid target has been initiated. The radioiodine is isolated by a dry distillation technique from the target matrix. The mass and oxidation states of iodine species isolated from the processing were analyzed using high pressure liquid chromatography. Employing a C-8 reverse-phase column (1) and isocratic elution conditions;the chemical purity and specific activity of the various radioiodine species: was determined. The method provides a routine means for evaluation of the purity of the radioiodide prior to and post radiolabeling essential for the efficient utilization and recovery of this important radionuclide. |
| Keywords: | positron emission tomography; tumor; radioimmunotherapy; i-124 |
| Journal Title | AIP Conference Proceedings |
| Volume: | 475 |
| Conference Dates: | 1998 Nov 4-7 |
| Conference Location: | Denton, TX |
| ISBN: | 0094-243X |
| Publisher: | American Institute of Physics |
| Date Published: | 1999-06-10 |
| Start Page: | 984 |
| End Page: | 986 |
| Language: | English |
| ACCESSION: | WOS:000081503200235 |
| PROVIDER: | wos |
| DOI: | 10.1063/1.59085 |
| Notes: | Proceedings Paper -- Source: Wos |
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