Treatment of localized esophageal cancer Journal Article
| Authors: | Brenner, B.; Ilson, D. H.; Minsky, B. D. |
| Article Title: | Treatment of localized esophageal cancer |
| Abstract: | The treatment of localized esophageal cancer (LEC) is controversial. The approaches that are used in daily practice include surgery or radiation alone, preoperative or postoperative radiation, preoperative or postoperative chemotherapy, and definitive or preoperative chemoradiation. The varied modalities used to treat LEC reflect both the lack of randomized trial data and the suboptimal results with current therapy. Nonetheless, the available data suggest that surgery and definitive concurrent chemoradiation represent two standard treatment options. The use of preoperative chemoradiation remains investigational, with phase III trials failing to demonstrate a consistent benefit for this option over chemoradiation or surgery alone. This review will examine the available data on the current treatment approaches in LEC. © 2004 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; cancer surgery; surgical technique; treatment failure; clinical trial; drug tolerability; review; cancer localization; cancer recurrence; cisplatin; fluorouracil; treatment planning; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; postoperative care; radiation dose; combined modality therapy; follow up; antineoplastic agent; etoposide; cancer mortality; vinblastine; docetaxel; irinotecan; survival time; folinic acid; bleomycin; surgical mortality; epirubicin; vindesine; preoperative treatment; esophagus cancer; esophageal neoplasms; humans; human; priority journal |
| Journal Title: | Seminars in Oncology |
| Volume: | 31 |
| Issue: | 4 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-08-01 |
| Start Page: | 554 |
| End Page: | 565 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2004.04.015 |
| PUBMED: | 15297946 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 23 September 2016 -- Source: Scopus |
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