Role of adjuvant therapy in adenocarcinoma of the rectum Journal Article


Author: Minsky, B. D.
Article Title: Role of adjuvant therapy in adenocarcinoma of the rectum
Abstract: Combined modality therapy is the standard adjuvant therapy for selected patients with adenocarcinoma of the rectum. In the postoperative setting, the primary goal is to decrease local recurrence and improve overall survival. In the preoperative setting, adjuvant therapy has the additional potential benefit of enhancing sphincter preservation and less acute toxicity as compared with postoperative adjuvant therapy. Investigational trials are in progress to examine new systemic chemotherapeutic agents and altered radiation fractionation schemes.
Keywords: cancer chemotherapy; treatment outcome; disease-free survival; cancer surgery; surgical technique; survival rate; review; fluorouracil; diarrhea; multimodality cancer therapy; treatment planning; capecitabine; cancer adjuvant therapy; cancer radiotherapy; postoperative care; preoperative care; radiation dose; chemotherapy, adjuvant; combined modality therapy; radiotherapy, adjuvant; cancer staging; neoplasm staging; adenocarcinoma; ki 67 antigen; bolus injection; leukopenia; vincristine; continuous infusion; tumor marker; prediction; lomustine; radiation dosage; irinotecan; postoperative complications; folinic acid; adjuvant chemotherapy; cycline; oxaliplatin; thymidylate synthase inhibitor; rectum carcinoma; rectal neoplasms; intestine function; adjuvant radiotherapy; leucovorin; drug administration routes; intravenous drug administration; small intestine obstruction; biological tumor markers; raltitrexed; 5 chloro 2,4 dihydroxypyridine plus oxonate potassium plus tegafur; levamisole; uft; trimetrexate; edrecolomab; semustine; anus; humans; human; priority journal; 5 ethynyluracil; combined antineoplastic agents; high- energy radiotherapy; mesentery/surgery
Journal Title: Seminars in Surgical Oncology
Volume: 17
Issue: 3
ISSN: 8756-0437
Publisher: John Wiley & Sons  
Date Published: 1999-10-01
Start Page: 189
End Page: 198
Language: English
DOI: 10.1002/(sici)1098-2388(199910/11)17:3<189::aid-ssu8>3.0.co;2-h
PUBMED: 10504667
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 16 August 2016 -- Source: Scopus
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  1. Bruce Minsky
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