Evaluating prostate cancer using fractional tissue composition of radical prostatectomy specimens and pre-operative diffusional kurtosis magnetic resonance imaging Journal Article

   

Authors:	Lawrence, E. M.; Warren, A. Y.; Priest, A. N.; Barrett, T.; Goldman, D. A.; Gill, A. B.; Gnanapragasam, V. J.; Sala, E.; Gallagher, F. A.
Article Title:	Evaluating prostate cancer using fractional tissue composition of radical prostatectomy specimens and pre-operative diffusional kurtosis magnetic resonance imaging
Abstract:	Background: Evaluating tissue heterogeneity using non-invasive imaging could potentially improve prostate cancer assessment and treatment. Methods: 20 patients with intermediate/high-risk prostate cancer underwent diffusion kurtosis imaging, including calculation of apparent diffusion (Dapp) and kurtosis (Kapp), prior to radical prostatectomy. Whole-mount tissue composition was quantified into: cellularity, luminal space, and fibromuscular stroma. Peripheral zone tumors were subdivided according to Gleason score. Results: Peripheral zone tumors had increased cellularity (p<0.0001), decreased fibromuscular stroma (p<0.05) and decreased luminal space (p<0.0001). Gleason score ≥4+3 tumors had significantly increased cellularity and decreased fibromuscular stroma compared to Gleason score ≤3+4 (p<0.05). In tumors, there was a significant positive correlation between median Kapp and cellularity (ρ = 0.50; p<0.05), and a negative correlation with fibromuscular stroma (ρ = -0.45; p<0.05). In normal tissue, median Dapp had a significant positive correlation with luminal space (ρ = 0.65; p<0.05) and a negative correlation with cellularity (ρ = -0.49; p<0.05). Median Kapp and Dapp varied significantly between tumor and normal tissue (p<0.0001), but only median Kapp was significantly different between Gleason score ≥4+3 and ≤3+4 (p<0.05). Conclusions: Peripheral zone tumors have increased cellular heterogeneity which is reflected in mean Kapp, while normal prostate has a more homogeneous luminal space and cellularity better represented by Dapp. © 2016 Lawrence et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords:	adult; clinical article; controlled study; human tissue; aged; histopathology; preoperative evaluation; prospective study; controlled clinical trial; tumor volume; cell heterogeneity; prostate cancer; gleason score; tissue section; prostatectomy; prostate tumor; diffusion weighted imaging; tissue structure; nuclear magnetic resonance scanner; radiological parameters; cellularity; human; male; article; apparent diffusion; apparent kurtosis; diffusional kurtosis imaging; fibromuscular stromal matrix; luminal space; peripheral zone tumor
Journal Title:	PLoS ONE
Volume:	11
Issue:	7
ISSN:	1932-6203
Publisher:	Public Library of Science
Date Published:	2016-07-28
Start Page:	e0159652
Language:	English
DOI:	10.1371/journal.pone.0159652
PROVIDER:	scopus
PMCID:	PMC4965080
PUBMED:	27467064
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84982665585&partnerID=40&md5=613a684283804d0c85b1407c0eeb9135
Notes:	Article -- Export Date: 1 September 2016 -- Source: Scopus

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