The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior Journal Article
| Authors: | Liu, Y.; Elf, S. E.; Asai, T.; Miyata, Y.; Sashida, G.; Huang, G.; Di Giandomenico, S.; Koff, A.; Nimer, S. D. |
| Article Title: | The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior |
| Abstract: | In response to diverse stresses, the tumor suppressor p53 differentially regulates its target genes, variably inducing cell cycle arrest, apoptosis or senescence. Emerging evidence indicates that p53 plays an important role in regulating hematopoietic stem cell (HSC) quiescence, self-renewal, apoptosis and aging. The p53 pathway is activated by DNA damage, defects in ribosome biogenesis, oxidative stress and oncogene induced p19ARF upregulation. We present an overview of the current state of knowledge about p53 (and its target genes) in regulating HSC behavior, with the hope that understanding the molecular mechanisms that control p53 activity in HSCs and how p53 mutations affect its role in these events may facilitate the development of therapeutic strategies for eliminating leukemia (and cancer) propagating cells. © 2009 Landes Bioscience. |
| Keywords: | leukemia; review; nonhuman; dna damage; gene targeting; cell cycle; cell function; apoptosis; gene expression; cell growth; cell renewal; protein p53; transcription factors; myelodysplastic syndrome; cell transformation; hematopoietic stem cells; tumor suppressor protein p53; cell cycle arrest; hematopoiesis; aging; upregulation; oxidative stress; hematopoietic stem cell; senescence; tumor suppressor protein; transcription factor slug; self-renewal; cell aging; transcription factor e2f1; cell strain 3t3; p53; gfi-1; leukemia stem cell; necdin; p21; quiescence; slug; cyclin dependent kinase inhibitor 2c; protein mdm2; puma protein; ribosome protein; transcription factor ets; biogenesis; cell stress; targeted gene repair; proto-oncogene proteins c-mdm2 |
| Journal Title: | Cell Cycle |
| Volume: | 8 |
| Issue: | 19 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2009-10-01 |
| Start Page: | 3120 |
| End Page: | 3124 |
| Language: | English |
| PUBMED: | 19755852 |
| PROVIDER: | scopus |
| PMCID: | PMC4637974 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 30 November 2010" - "Source: Scopus" |
